Modelo experimental de úlcera traumática em mucosa jugal de ratos

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dc.contributor.authorCavalcante, Galyléia Meneses
dc.contributor.authorde Paula, Renata Janaína Sousa
dc.contributor.authorde Souza, Leonardo Peres [UNESP]
dc.contributor.authorSousa, Fabrício Bitu
dc.contributor.authorMota, Mário Rogério Lima
dc.contributor.authorAlves, Ana Paula Negreiros Nunes
dc.contributor.institutionUFC
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionOdontology and Nursing College
dc.date.accessioned2014-05-27T11:25:52Z
dc.date.available2014-05-27T11:25:52Z
dc.date.issued2011-05-01
dc.description.abstractPurpose: To establish an experimental model of traumatic ulcer in rat cheek mucosa for utilization in future alternative therapy studies. Methods: A total of 60 adult male rats (250 - 300g) were used. Ulceration of the left cheek mucosa was provoked by abrasion using a n o 15 scalpel blade. The animals were observed for 10 days, during which they were weighed and their ulcers were measured. The histological characteristics were analyzed and scored according to the ulcer phase. In the statistical analysis, a value of p<0.01 was considered a statistically significant response in all cases. Results: During the five first days, the animals lost weight (Student t test, p<0.01). The ulcerated area receded linearly over time and was almost completely cicatrized after 10 days (ANOVA, Tendency post-test, p<0.0001). Groups on days 1, 2 and 3 days displayed similar results, but a decrease in scores were observed after the 4th day. Conclusion: The proposed cheek mucosa ulcer model in rats can be considered an efficient, low-cost, reliable, and reproducible method.en
dc.description.affiliationUFC, Ceara
dc.description.affiliationDepartment of Cellular and Molecular Biology Sao Paulo State University (UNESP)
dc.description.affiliationClinical Odontology, Pharmacy Odontology and Nursing College
dc.description.affiliationUnespDepartment of Cellular and Molecular Biology Sao Paulo State University (UNESP)
dc.format.extent227-234
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502011000300012
dc.identifier.citationActa Cirurgica Brasileira, v. 26, n. 3, p. 227-234, 2011.
dc.identifier.doi10.1590/S0102-86502011000300012
dc.identifier.file2-s2.0-79955879781.pdf
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.scieloS0102-86502011000300012
dc.identifier.scopus2-s2.0-79955879781
dc.identifier.urihttp://hdl.handle.net/11449/72406
dc.language.isopor
dc.relation.ispartofActa Cirúrgica Brasileira
dc.relation.ispartofjcr0.933
dc.relation.ispartofsjr0,395
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectMouth mucosa
dc.subjectRats
dc.subjectUlcer
dc.subjectWound heling
dc.subjectabrasion
dc.subjectanalysis of variance
dc.subjectanimal experiment
dc.subjectanimal model
dc.subjectanimal tissue
dc.subjectbody weight
dc.subjectcheek mucosa
dc.subjectcost
dc.subjectdisease course
dc.subjecthistology
dc.subjectmale
dc.subjectmouth ulcer
dc.subjectnonhuman
dc.subjectrat
dc.subjectreliability
dc.subjectreproducibility
dc.subjectscalpel
dc.subjectscoring system
dc.subjectweight reduction
dc.subjectAnimals
dc.subjectCheek
dc.subjectDisease Models, Animal
dc.subjectMale
dc.subjectMouth Mucosa
dc.subjectOral Ulcer
dc.subjectTime Factors
dc.subjectWound Healing
dc.titleModelo experimental de úlcera traumática em mucosa jugal de ratospt
dc.title.alternativeExperimental model of traumatic ulcer in the cheek mucosa of ratsen
dc.typeArtigo
dcterms.licensehttp://www.scielo.br/revistas/acb/iaboutj.htm

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