Developmental changes in cold tolerance and ability to autoresuscitate from hypothermic respiratory arrest are not linked in rats and hamsters

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dc.contributor.authorCorcoran, Andrea E.
dc.contributor.authorAndrade, Denis V. [UNESP]
dc.contributor.authorMarshall, Lieneke H.
dc.contributor.authorMilsom, William K.
dc.contributor.institutionDartmouth Med Sch
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniv British Columbia
dc.date.accessioned2014-05-20T13:59:55Z
dc.date.available2014-05-20T13:59:55Z
dc.date.issued2012-05-31
dc.description.abstractIn adult mammals, severe hypothermia leads to respiratory and cardiac arrest, followed by death. Neonatal rats and hamsters can survive much lower body temperatures and, upon artificial rewarming, spontaneously recover from respiratory arrest (autoresuscitate), typically suffering no long-term effects. To determine developmental and species differences in cold tolerance (defined here as the temperature of respiratory arrest) and its relation to the ability to autoresuscitate, we cooled neonatal and juvenile Sprague-Dawley rats and Syrian hamsters until respiration ceased, followed by rewarming. Ventilation and heartbeat were continuously monitored. In rats, cold tolerance did not change throughout development, however the ability to autoresuscitate from hypothermic respiratory arrest did (lost between postnatal days, P, 14 and 20), suggesting that the mechanisms for maintaining breathing at low temperatures was retained throughout development while those initiating breathing on rewarming were altered. Hamsters, however, showed increased cold tolerance until P26-28 and were able to autoresuscitate into adulthood (provided the heart kept beating throughout respiratory arrest). Also, hamsters were more cold tolerant than rats. We saw no evidence of gasping to initiate breathing following respiratory arrest, contributing to the hypothesis that hypothermic respiratory arrest does not lead to anoxia. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationDartmouth Med Sch, Dept Physiol & Neurobiol, Lebanon, NH 03756 USA
dc.description.affiliationUniv Estadual Paulista, Dept Zool, Rio Claro, SP, Brazil
dc.description.affiliationUniv British Columbia, Dept Zool, Vancouver, BC V5Z 1M9, Canada
dc.description.affiliationUnespUniv Estadual Paulista, Dept Zool, Rio Claro, SP, Brazil
dc.format.extent249-258
dc.identifierhttp://dx.doi.org/10.1016/j.resp.2012.03.006
dc.identifier.citationRespiratory Physiology & Neurobiology. Amsterdam: Elsevier B.V., v. 181, n. 3, p. 249-258, 2012.
dc.identifier.doi10.1016/j.resp.2012.03.006
dc.identifier.issn1569-9048
dc.identifier.urihttp://hdl.handle.net/11449/21187
dc.identifier.wosWOS:000305657200001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofRespiratory Physiology & Neurobiology
dc.relation.ispartofjcr1.792
dc.relation.ispartofsjr0,682
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectRespiratory controlen
dc.subjectPostnatal developmenten
dc.subjectCold toleranceen
dc.subjectAutoresuscitationen
dc.subjectRaten
dc.subjectHamsteren
dc.titleDevelopmental changes in cold tolerance and ability to autoresuscitate from hypothermic respiratory arrest are not linked in rats and hamstersen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
unesp.author.orcid0000-0002-7662-2848[2]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Rio Claropt

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