Pubertal exposure to ethinylestradiol promotes different effects on the morphology of the prostate of the male and female gerbil during aging

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dc.contributor.authorPerez, Ana P. S.
dc.contributor.authorBiancardi, Manoel F.
dc.contributor.authorCaires, Cássia R. S. [UNESP]
dc.contributor.authorFalleiros, Luiz R. [UNESP]
dc.contributor.authorGóes, Rejane M. [UNESP]
dc.contributor.authorSantos, Fernanda C. A.
dc.contributor.authorTaboga, Sebastião R. [UNESP]
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade Federal de Goiás (UFG)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:01:31Z
dc.date.available2018-12-11T17:01:31Z
dc.date.issued2017-02-01
dc.description.abstractIn rodents, the final growth and maturation of the prostate occur at puberty, a crucial period for prostate development. The present study is a serological, morphological, morphometric, and immunohistochemical analysis of the effects of exposure to ethinylestradiol (EE) (15 µg/kg/day) during puberty (EE/PUB group) on the male ventral and female prostate in senile gerbils. In the study, male and female gerbils (Meriones unguiculatus) (42 days) received by gavage 15 μg/kg/day of EE (a component of the contraceptive pill), diluted in 100 µL of Nujol® for 1 week (EE/PUB group). In the control group, males and females were not treated. Animals were killed (n = 5) after 12 months in the experimental groups. In the senile male in the EE/PUB group, we observed a reduction in testosterone levels and a decrease in the prostatic epithelial thickness, as well as in the thickness of the muscle layer. In addition, an increase in PIN multiplicity and prostatic inflammation was observed. In the senile female in the EE/PUB group, we observed increased testosterone and estradiol levels, an enhanced prostatic epithelial thickness and an increase in the thickness of the muscle layer. Immunohistochemical analysis revealed an increase in positive cells (%) for AR and PCNA in the male prostate and an increase in positive basal cells for p63 in the female prostate of the EE/PUB group. Exposure to EE during puberty resulted in an inhibitory action on the male ventral prostate and an anabolic effect on the female prostate in senile gerbils. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 477–489, 2017.en
dc.description.affiliationDepartment of Structural and Functional Biology Institute of Biology UNICAMP, CP 6109
dc.description.affiliationSpecial Institute of Health Sciences Medicine Course Federal University of Goiás
dc.description.affiliationDepartment of Biology Laboratory of Microscopy and Microanalysis IBILCE University of Estadual Paulista—UNESP
dc.description.affiliationDepartment of Morphology Federal University of Goiás
dc.description.affiliationUnespDepartment of Biology Laboratory of Microscopy and Microanalysis IBILCE University of Estadual Paulista—UNESP
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2009-16790-5
dc.description.sponsorshipIdFAPESP: 2011/06335-9
dc.format.extent477-489
dc.identifierhttp://dx.doi.org/10.1002/tox.22252
dc.identifier.citationEnvironmental Toxicology, v. 32, n. 2, p. 477-489, 2017.
dc.identifier.doi10.1002/tox.22252
dc.identifier.issn1522-7278
dc.identifier.issn1520-4081
dc.identifier.scopus2-s2.0-84959547771
dc.identifier.urihttp://hdl.handle.net/11449/172632
dc.language.isoeng
dc.relation.ispartofEnvironmental Toxicology
dc.relation.ispartofsjr0,652
dc.relation.ispartofsjr0,652
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectethinylestradiol
dc.subjectfemale
dc.subjectmale
dc.subjectprostate
dc.subjectpuberty
dc.subjectsenescence
dc.titlePubertal exposure to ethinylestradiol promotes different effects on the morphology of the prostate of the male and female gerbil during agingen
dc.typeArtigo
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