Genotoxicity and cytotoxicity induced by municipal effluent in multiple organs of Wistar rats

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dc.contributor.authorPereira da Silva, Victor Hugo
dc.contributor.authorGomes de Moura, Carolina Foot
dc.contributor.authorPidone Ribeiro, Flavia Andressa
dc.contributor.authorCesar, Augusto
dc.contributor.authorSeabra Pereira, Camilo Dias
dc.contributor.authorDias Silva, Marcelo Jose [UNESP]
dc.contributor.authorVilegas, Wagner [UNESP]
dc.contributor.authorRibeiro, Daniel Araki
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-03-18T15:53:08Z
dc.date.available2015-03-18T15:53:08Z
dc.date.issued2014-11-01
dc.description.abstractThe aim of this study was to evaluate cytotoxicity and genotoxicity in multiple organs of rats induced by municipal effluent released by submarine outfall in city of Santos. A total of 20 male Wistar rats were exposed to effluents by drinking water ad libitum at concentrations of 0, 10, 50, and 100% for 30 days. Microscopic analysis revealed severe lesions such as necrosis and hemorrhagic areas in liver and kidney from animals exposed to effluent at 50 and 100% concentration. DNA damage in peripheral blood, liver, and kidney cells were detected by comet assay at higher concentrations of effluent. Moreover, a decrease DNA repair capacity was detected in liver cells. Significant statistical differences (p<0.05) for micronucleated cells from liver were noticed at 50% concentration of effluent. Taken together, our results demonstrate that municipal effluent is able to induce cytotoxicity and genotoxicity in multiple organs of Wistar rats.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Biosci, BR-11060001 Santos, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Dept Pathol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Marine Sci, UNIFESP, Sao Paulo, SP, Brazil
dc.description.affiliationSao Paulo State Univ, UNESP, Sao Vicente, SP, Brazil
dc.description.affiliationUnespSao Paulo State Univ, UNESP, Sao Vicente, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent13069-13080
dc.identifierhttp://dx.doi.org/10.1007/s11356-014-3261-5
dc.identifier.citationEnvironmental Science And Pollution Research. Heidelberg: Springer Heidelberg, v. 21, n. 22, p. 13069-13080, 2014.
dc.identifier.doi10.1007/s11356-014-3261-5
dc.identifier.issn0944-1344
dc.identifier.lattes7927877224326837
dc.identifier.orcid0000-0003-3032-2556
dc.identifier.urihttp://hdl.handle.net/11449/116360
dc.identifier.wosWOS:000344546900043
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofEnvironmental Science And Pollution Research
dc.relation.ispartofjcr2.800
dc.relation.ispartofsjr0,858
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectMunicipal effluenten
dc.subjectApoptosisen
dc.subjectMutagenicityen
dc.subjectDNA damageen
dc.subjectRaten
dc.titleGenotoxicity and cytotoxicity induced by municipal effluent in multiple organs of Wistar ratsen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
unesp.author.lattes7927877224326837
unesp.author.orcid0000-0003-3032-2556[7]
unesp.author.orcid0000-0001-8357-8112[5]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, São Vicentept
unesp.departmentCiências Biológicas - IBCLPpt

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São Vicente - IBCLP - Instituto de Biociências