Behavioral, climatic, and environmental risk factors for Zika and Chikungunya virus infections in Rio de Janeiro, Brazil, 2015-16

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dc.contributor.authorFuller, Trevon L.
dc.contributor.authorCalvet, Guilherme
dc.contributor.authorEstevam, Camila Genaro [UNESP]
dc.contributor.authorAngelo, Jussara Rafael
dc.contributor.authorAbiodun, Gbenga J.
dc.contributor.authorHalai, Umme-Aiman
dc.contributor.authorDe Santis, Bianca
dc.contributor.authorSequeira, Patricia Carvalho
dc.contributor.authorAraujo, Eliane Machado
dc.contributor.authorSampaio, Simone Alves
dc.contributor.authorDe Mendonça, Marco Cesar Lima
dc.contributor.authorFabri, Allison
dc.contributor.authorRibeiro, Rita Maria
dc.contributor.authorHarrigan, Ryan
dc.contributor.authorSmith, Thomas B.
dc.contributor.authorGabaglia, Claudia Raja
dc.contributor.authorBrasil, Patrícia
dc.contributor.authorDe Filippis, Ana Maria Bispo
dc.contributor.authorNielsen-Saines, Karin
dc.contributor.institutionUniversity of California Los Angeles
dc.contributor.institutionFundação Oswaldo Cruz
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFoundation for Professional Development
dc.contributor.institutionDavid Geffen UCLA School of Medicine
dc.contributor.institutionBiomedical Research Institute of Southern California
dc.contributor.institutionCounty of Los Angeles Department of Public Health
dc.date.accessioned2022-04-28T19:07:06Z
dc.date.available2022-04-28T19:07:06Z
dc.date.issued2017-11-01
dc.description.abstractThe burden of arboviruses in the Americas is high and may result in long-term sequelae with infants disabled by Zika virus infection (ZIKV) and arthritis caused by infection with Chikungunya virus (CHIKV). We aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control and eventual vaccination. We screened sera and urine samples (n = 10,459) from residents of 48 municipalities in the state of Rio de Janeiro for CHIKV, dengue virus (DENV), and ZIKV by molecular PCR diagnostics. Further, we assessed the spatial pattern of arbovirus incidence at the municipal and neighborhood scales and the timing of epidemics and major rainfall events. Lab-confirmed cases included 1,717 infections with ZIKV (43.8%) and 2,170 with CHIKV (55.4%) and only 29 (<1%) with DENV. ZIKV incidence was greater in neighborhoods with little access to municipal water infrastructure (r = -0.47, p = 1.2x10-8). CHIKV incidence was weakly correlated with urbanization (r = 0.2, p = 0.02). Rains began in October 2015 and were followed one month later by the largest wave of ZIKV epidemic. ZIKV cases markedly declined in February 2016, which coincided with the start of a CHIKV outbreak. Rainfall predicted ZIKV and CHIKV with a lead time of 3 weeks each time. The association between rainfall and epidemics reflects vector ecology as the larval stages of Aedes aegypti require pools of water to develop. The temporal dynamics of ZIKV and CHIKV may be explained by the shorter incubation period of the viruses in the mosquito vector; 2 days for CHIKV versus 10 days for ZIKV.en
dc.description.affiliationInstitute of the Environment and Sustainability University of California Los Angeles
dc.description.affiliationInstituto Nacional de Infectologia Evandro Chagas Fundação Oswaldo Cruz
dc.description.affiliationUniversidade Estadual de São Paulo
dc.description.affiliationEscola Nacional de Saúde Pública Fundação Oswaldo Cruz
dc.description.affiliationFoundation for Professional Development
dc.description.affiliationDavid Geffen UCLA School of Medicine
dc.description.affiliationLaboratorio de Referência de Flavivirus Instituto Oswaldo Cruz Fundação Oswaldo Cruz
dc.description.affiliationDepartment of Ecology and Evolutionary Biology University of California Los Angeles
dc.description.affiliationBiomedical Research Institute of Southern California
dc.description.affiliationCounty of Los Angeles Department of Public Health
dc.description.affiliationUnespUniversidade Estadual de São Paulo
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação Oswaldo Cruz
dc.description.sponsorshipNational Science Foundation
dc.description.sponsorshipNational Institutes of Health
dc.description.sponsorshipHorizon 2020
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)
dc.description.sponsorshipIdNational Science Foundation: 1243524
dc.description.sponsorshipIdNational Institutes of Health: 1R21AI129534-01
dc.description.sponsorshipIdHorizon 2020: 734584
dc.description.sponsorshipIdHorizon 2020: 734857
dc.description.sponsorshipIdNational Institutes of Health: AI28697
dc.description.sponsorshipIdNational Institutes of Health: D43TW009343
dc.description.sponsorshipIdFAPERJ: E-18/2015TXB
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0188002
dc.identifier.citationPLoS ONE, v. 12, n. 11, 2017.
dc.identifier.doi10.1371/journal.pone.0188002
dc.identifier.issn1932-6203
dc.identifier.scopus2-s2.0-85034616861
dc.identifier.urihttp://hdl.handle.net/11449/220961
dc.language.isoeng
dc.relation.ispartofPLoS ONE
dc.sourceScopus
dc.titleBehavioral, climatic, and environmental risk factors for Zika and Chikungunya virus infections in Rio de Janeiro, Brazil, 2015-16en
dc.typeArtigo

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