Birth weight, biological maturation and obesity in adolescents: A mediation analysis

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dc.contributor.authorWerneck, A. O.
dc.contributor.authorSilva, D. R.P.
dc.contributor.authorCollings, P. J.
dc.contributor.authorFernandes, R. A. [UNESP]
dc.contributor.authorRonque, E. R.V.
dc.contributor.authorCoelho-E-Silva, M. J.
dc.contributor.authorSardinha, L. B.
dc.contributor.authorCyrino, E. S.
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)
dc.contributor.institutionBradford NHS Foundation Trust
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversity of Coimbra
dc.contributor.institutionUniversidade de Lisboa
dc.date.accessioned2018-12-11T16:46:59Z
dc.date.available2018-12-11T16:46:59Z
dc.date.issued2017-08-01
dc.description.abstractThis study was aimed to investigate associations between birth weight and multiple adiposity indicators in youth, and to examine potential mediating effects by biological maturation. This was a school-based study involving 981 Brazilian adolescents aged between 10 and 17 years. Birth weight was reported retrospectively by mothers. Maturation was estimated by age of peak height velocity. Adiposity indicators included body mass index (BMI), waist circumference and percent body fat estimated from triceps and subscapular skinfolds. Multilevel mediation analyses were performed using the Sobel test, adjusted for chronological age, gestational age, cardiorespiratory fitness and socio-economic status. Except for body fat in girls, biological maturation partly or fully mediated (P<0.05) positive relationships between birth weight with all other obesity indicators in both sexes with their respective values of indirect effects with 95% confidence intervals: BMI [boys: 0.44 (0.06-0.82); girls: 0.38 (0.13-0.64)], waist circumference [boys: 1.14 (0.22-2.05); girls: 0.87 (0.26-1.48)] and body fat [boys: 0.60 (0.13-1.07)]. To conclude, birth weight is associated with elevated obesity risk in adolescence and biological maturation seems to at least partly mediate this relationship.en
dc.description.affiliationStudy and Research Group in Metabolism Nutrition and Exercise - GEPEMENE State University of Londrina - UEL
dc.description.affiliationBradford Institute for Health Research Bradford NHS Foundation Trust
dc.description.affiliationScientific Research Group Related to Physical Activity (GICRAF) Laboratory of Investigation in Exercise (LIVE) Department of Physical Education São Paulo State University (UNESP)
dc.description.affiliationCIDAF (uid/dtp/04213/2016) University of Coimbra
dc.description.affiliationExercise and Health Laboratory CIPER Faculdade de Motricidade Humana Universidade de Lisboa
dc.description.affiliationUnespScientific Research Group Related to Physical Activity (GICRAF) Laboratory of Investigation in Exercise (LIVE) Department of Physical Education São Paulo State University (UNESP)
dc.format.extent502-507
dc.identifierhttp://dx.doi.org/10.1017/S2040174417000241
dc.identifier.citationJournal of Developmental Origins of Health and Disease, v. 8, n. 4, p. 502-507, 2017.
dc.identifier.doi10.1017/S2040174417000241
dc.identifier.file2-s2.0-85017646874.pdf
dc.identifier.issn2040-1752
dc.identifier.issn2040-1744
dc.identifier.lattes9913976858153343
dc.identifier.orcid0000-0003-1576-8090
dc.identifier.scopus2-s2.0-85017646874
dc.identifier.urihttp://hdl.handle.net/11449/169643
dc.language.isoeng
dc.relation.ispartofJournal of Developmental Origins of Health and Disease
dc.relation.ispartofsjr0,843
dc.relation.ispartofsjr0,843
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectadiposity
dc.subjectmotar activity
dc.subjectpuberty
dc.subjectsomatic maturation
dc.titleBirth weight, biological maturation and obesity in adolescents: A mediation analysisen
dc.typeArtigo
unesp.author.lattes9913976858153343[4]
unesp.author.orcid0000-0003-1576-8090[4]

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