Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys

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dc.contributor.authorPessoa, C. R M
dc.contributor.authorPessoa, A. F A
dc.contributor.authorMaia, L. A.
dc.contributor.authorMedeiros, R. M T
dc.contributor.authorColegate, S. M.
dc.contributor.authorBarros, S. S.
dc.contributor.authorSoares, M. P.
dc.contributor.authorBorges, Alexandre Secorun [UNESP]
dc.contributor.authorRiet-Correa, F.
dc.contributor.institutionFederal University of Campina Grande
dc.contributor.institutionUnited States Department of Agriculture
dc.contributor.institutionFederal University of Pelotas
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:30:33Z
dc.date.available2014-05-27T11:30:33Z
dc.date.issued2013-09-01
dc.description.abstractThe effects and susceptibility of donkeys to Crotalaria juncea and Crotalaria retusa poisoning were determined at high and low doses. Seeds of C. juncea containing 0.074% of dehydropyrrolizidine alkaloids (DHPAs) (isohemijunceines 0.05%, trichodesmine 0.016%, and junceine 0.008%) were administered to three donkeys at 0.3, 0.6 and 1g/kg body weight (g/kg) daily for 365 days. No clinical signs were observed and, on liver and lung biopsies, the only lesion was a mild liver megalocytosis in the donkeys ingesting 0.6 and 1g/kg/day. Two other donkeys that received daily doses of 3 and 5g seed/kg showed initial respiratory signs 70 and 40 days after the start of the administration, respectively. The donkeys were euthanized following severe respiratory signs and the main lung lesions were proliferation of Clara cells and interstitial fibrosis. Three donkeys ingested seeds of C. retusa containing 5.99% of monocrotaline at daily doses of 0.025, 0.05 and 0.1g/kg for 365 days. No clinical signs were observed and, on liver and lung biopsies, the only lesion was moderate liver megalocytosis in each of the three donkeys. One donkey that received a single dose of 5g/kg of C. retusa seeds and another that received 1g/kg daily for 7 days both showed severe clinical signs and died with diffuse centrilobular liver necrosis. No lung lesions were observed. Another donkey that received a single dose of 2.5g/kg of C. retusa seeds showed no clinical signs. The hepatic and pneumotoxic effects observed are consistent with an etiology involving DHPAs. Furthermore, the occurrence of lung or liver lesions correlates with the type of DHPAs contained in the seeds. Similarly as has been reported for horses, the data herein suggest that in donkeys some DHPAs are metabolized in the liver causing liver disease, whereas others are metabolized in the lung by Clara cells causing lung disease. © 2013 Elsevier Ltd.en
dc.description.affiliationVeterinary Hospital Federal University of Campina Grande, Patos, CEP 58700-310 Paraíba
dc.description.affiliationPoisonous Plant Research Laboratory Agricultural Research Service United States Department of Agriculture, 1150 E. 1400 N., Logan, UT 84341
dc.description.affiliationRegional Diagnostic Laboratory Federal University of Pelotas, 96010-900 Pelotas, Rio Grande do Sul
dc.description.affiliationDepartment of Veterinary Clinical Science College of Veterinary Medicine and Animal Science - Univ Estadual Paulista (UNESP), Botucatu, São Paulo CEP 18618-970
dc.description.affiliationUnespDepartment of Veterinary Clinical Science College of Veterinary Medicine and Animal Science - Univ Estadual Paulista (UNESP), Botucatu, São Paulo CEP 18618-970
dc.format.extent113-120
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2013.05.007
dc.identifier.citationToxicon, v. 71, p. 113-120.
dc.identifier.doi10.1016/j.toxicon.2013.05.007
dc.identifier.issn0041-0101
dc.identifier.issn1879-3150
dc.identifier.lattes9643433706163946
dc.identifier.scopus2-s2.0-84879538968
dc.identifier.urihttp://hdl.handle.net/11449/76422
dc.identifier.wosWOS:000322208100014
dc.language.isoeng
dc.relation.ispartofToxicon
dc.relation.ispartofjcr2.352
dc.relation.ispartofsjr0,692
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectClara cells
dc.subjectCrotalaria juncea
dc.subjectCrotalaria retusa
dc.subjectDehydropyrrolizidine alkaloids
dc.subjectDonkey
dc.subjectPneumotoxicity
dc.subjectalkaloid
dc.subjectaspartate aminotransferase
dc.subjectdehydropyrrolizidine alkaloid
dc.subjectgamma glutamyltransferase
dc.subjectisohemijunceine
dc.subjectjunceine
dc.subjectmonocrotaline
dc.subjecttrichodesmine
dc.subjectunclassified drug
dc.subjectanimal experiment
dc.subjectanimal tissue
dc.subjectanorexia
dc.subjectaspartate aminotransferase blood level
dc.subjectatelectasis
dc.subjectcell proliferation
dc.subjectClara cell
dc.subjectcontrolled study
dc.subjectCrotalaria
dc.subjectcrotalaria juncea
dc.subjectdonkey
dc.subjectdyspnea
dc.subjectfibrosing alveolitis
dc.subjectliver biopsy
dc.subjectliver necrosis
dc.subjectliver toxicity
dc.subjectlung biopsy
dc.subjectlung edema
dc.subjectlung emphysema
dc.subjectlung nodule
dc.subjectlung toxicity
dc.subjectmegalocytosis
dc.subjectneutrophil chemotaxis
dc.subjectnonhuman
dc.subjectplant seed
dc.subjectpriority journal
dc.titlePulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeysen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
unesp.author.lattes9643433706163946[8]
unesp.author.orcid0000-0001-6256-8089[8]
unesp.campusUniversidade Estadual Paulista (Unesp), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt

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