Departamento:
Departamento de Fármacos e Medicamentos

Sigla

DFM

Página da web

https://www2.fcfar.unesp.br/#!/instituicao/departamentos/farmacos-e-medicamentos-novo/

URI

https://hdl.handle.net/11449/295945

Página do item completo

Unidades

Unidade

Faculdade de Ciências Farmacêuticas

FCF

Campus: Araraquara

Resultados da pesquisa de publicação

Agora exibindo 1 - 10 de 1193

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Development and characterization of cefoxitin loaded D,L-PLA nanoparticles
(2010) Machado, Silvia Regina Pengo ; Evangelista, Raul Cesar ; Universidade Metodista de Piracicaba (UNIMEP) ; Universidade Estadual Paulista (Unesp)
Nanoparticles containing cefoxitin (CEF) made of D,L-PLA (PLA) were designed by a multiple emulsion/solvent evaporation method. The particles were extensively evaluated in relation to morphology, encapsulation efficiency, drug-polymer interactions as well as in vitro drug release kinetics. Nanoparticles were spherical in shape and isolated, with a mean diameter of about 600 nm. The thermal behaviour (DSC) of CEF-containing nanoparticles suggested that the drug was dispersed at a molecular level within the system. The drug encapsulation efficiency in the system for a CEF concentration of 30 mg/mL was 5.5%, as assessed after the drug extraction, by a validated HPLC method. This low encapsulation efficiency is understandable, since CEF is highly hydrophilic. The in vitro assays showed a strong sustained drug release profile from the nanoparticles with kinetics following pure Fickian diffusion.
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Assessment of pharmacotherapeutic safety of medical prescriptions for elderly residents in a long-term care facility
(Universidade de São Paulo (USP), Conjunto Quimicas, 2012-07-01) Varallo, Fabiana Rossi ; Stein Ambiel, Ingrid Stephanie ; Nanci, Luana Orlandelli ; Fernandes Galduroz, Jose Carlos ; Mastroianni, Patricia de Carvalho ; Universidade Estadual Paulista (Unesp) ; Universidade Federal de São Paulo (UNIFESP)
The present study aimed to estimate the prevalence of elderly using potentially inappropriate medications (PIM) and with occurrence of potentially hazardous drug interactions (PHDI), to identify the risk factors for the prescription of PIM and to evaluate the impact of pharmaceutical intervention (PI) for the prescription of safer therapeutic alternatives. Therefore, a cross-sectional study was performed in a long-term care facility in São Paulo State, between December/2010 and January/2011. The medical records of the patients >= 60 years old who took any drugs were consulted to assess the pharmacotherapeutic safety of the medical prescriptions, in order to identify PIM and PHDI, according to the Beers (2003) and World Health Organization criteria, respectively. PI consisted of a guidance letter to the physician responsible for the institution, with the suggestions of safer equivalent therapeutics. Approximately 88% of the elderly took at least one drug, and for 30% of them the PIM had been prescribed. Most of the PIM identified (53.4%) act on the central nervous system. Among the 13 different DI detected, 6 are considered PHDI. Polypharmacy was detected as a risk factor for PIM prescription. After the PI there was no change in medical prescriptions of patients who had been prescribed PIM or PHDI. The data suggests that PI performed by letter, as the only interventional, method was ineffective. To contribute it a wide dissemination of PIM and PHDI among prescriber professionals is necessary for the selection of safer treatment for elderly. Additionally, a pharmacist should be part of the health care team in order to help promote rational use of medicines.
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Acesso, segurança e uso de medicamentos por usuários
(2012) Andrade, Raul Vasconcelos ; Farache Filho, Adalberto ; Galduróz, José Carlos ; Mastroianni, Patricia de Carvalho ; Universidade Estadual Paulista (Unesp) ; Universidade Federal de São Paulo (UNIFESP)
The present study aims to identify families who have stock and are making use of medications, as well as assess the conditions of storage, security and use of these drugs. The study was conducted in a city of São Paulo, the interviews were conducted in households enrolled in one of ten units of the Estratégia de Saúde da Família (ESF) that the city provides and the sample was defined by means of stratified random sampling (134households, IC 95%). Data collection was conducted through interviews with a semistructured questionnaire during the first half of 2011. We interviewed 118 (88.0%) households, of which 112 (95.0%) had medications that were stored n insecure or inadequate places in 75.4% of households, non-prescription self-medication was a common practice in 46 (47 4%) households, and lack of identification and security of medications stored was observed in 60 (53.6%) households. Most households had stock of medicines, which were done improperly or unsecure, or have specialties with lack of identification and security, which can lead to poisoning or e ineffective therapy. The Pharmaceutical Assistance under SUS lacks social initiatives, with actions directed for medications users, which can be supplied by the presence of the pharmacist in the ESF, essential for the promotion of racional use of medicines, that, through the Pharmaceutical Care, can identify, correct and prevent possible problems related to drugs.
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Estoque doméstico e uso de medicamentos em uma população cadastrada na estratégia saúde da família no Brasil
(Pan Amer Health Organization, 2011-05-01) Mastroianni, Patricia de Carvalho ; Lucchetta, Rosa Camila ; Sarra, Josiane dos Reis ; Fernandez Galduroz, Jose Carlos ; Universidade Estadual Paulista (Unesp) ; Universidade Federal de São Paulo (UNIFESP)
Objective. To identify families served by the family health strategy (FHS) storing medicines at home, to evaluate storage conditions, and to investigate medicine use practices.Methods. The study was conducted in a municipality in the state of São Paulo with two FHS units serving 1 867 households. The sample was selected by means of stratified random sampling. Data collection was conducted through semistructured interviews from July to October 2008.Results. One resident was interviewed in each of the 280 households visited. Medicines were found in 255 households (91.1%). of 326 storage locations, 217 (75.8%) were inadequate (easily accessible to children or exposed to moisture, light). of the 2 578 medicines identified, 2 059 medicines (79.9%) in 236 (84.3%) households had safety or identification problems. of the 280 respondents, 179 (63.9%) used medications. of these, 24 were self-medicating, only one with an over-the-counter drug. Only 44 users had the prescription for their medication, and 21 did not follow the prescription in terms of dosage or had interrupted the treatment.Conclusions. Non-adherence to recommended treatment can lead to negative outcomes, such as inefficiency (using dosages lower than prescribed), poisoning (using dosages higher than prescribed), and other adverse reactions.
Microbiological Assay for the Determination of Colistin Sulphate
(Bentham Science Publ Ltd, 2014-01-01) Calixto, Giovana ; Domingos, Luciana Elisete ; Fabri, Nathalie Thomazini ; Carmo, Thais Adriana do ; Moreno, Andreia de Haro ; Salgado, Hérida Regina Nunes ; Chorilli, Marlus ; Universidade Estadual Paulista (Unesp) ; Univ Metodista Piracicaba
An innovative microbiological assay was developed for the determination of colistin sulphate at various concentrations (192-469 IU/mL); using Bordetella bronchiseptica ATCC 4617 as microorganism test. This assay revealed subtle changes not demonstrated by chemical methods, such as chemical degradation and low of potency, but by evaluating the potency of colistin, which is very important for the analysis of antibiotics. The method was validated according to ICH guidelines, proving to be linear ( r(2) = 0.9985), precise ( CV = 1.32%) and accurate ( 100.9 +/- 1.33%). It was concluded that the microbiological assay is satisfactory for in vitro quantitation of the antibacterial activity of colistin sulphate.
Acesso Aberto
Development of organic-inorganic polymeric film formers for controlled drug release and wound care
(Univ Fed Rio De Janeiro, Lab Hidrogenio, 2014-01-01) Oshiro Junior, Joao Augusto ; Shiota, Leticia Moriya ; Chiavacci, Leila Aparecida ; Universidade Estadual Paulista (Unesp)
Film forming polymeric systems represents a new and unexplored technology of systems forskin or wounds protection and for controlled drug release. The aim of this work was to study the use of polymeric organic-inorganic ureasil-polyether hybrids synthesized by the sol-gel process as film forming system containing silver sulfadiazine as model drug. The film formationtime can be controlled by changing the precursor/catalyst ratio used during the step of hydrolysis and condensations. The results showed that the precursor/catalyst proportion influences both the visual characteristics and time required to form the film. The precursor/catalyst ratio equal to 20.8 m/v was considered ideal due to promote the homogeneous and transparent film formation in less than 5 minutes. The release profile of sulfadiazine is dependent on the characteristics of the matrixes: matrix more hydrophobic as ureasil-POP provided a slowed released mainly due to the low swelling of the matrix. The more hydrophilic ureasil-POE matrix presents a large capacity to swell and favors the faster release of the drug. The set of results showed the possibility of future use of these systems for treating wounds caused by burns.
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Avaliação da atividade fotoprotetora de Achillea millefolium L. (Asteraceae)
(Sociedade Brasileira de Farmacognosia, 2005-03-01) Souza, T.M. ; Santos, L.E. ; Moreira, R.R.D. ; Rangel, V.L.B.I. ; Universidade Estadual Paulista (Unesp)
As radiações ultravioleta (divididas em ultravioleta A, B e C), por possuírem diferentes energias e comprimentos de onda, apresentam diferentes atividades sobre os organismos, sendo que algumas destas atividades são benéficas e outras, não. A fim de evitar os malefícios causados por estas radiações, existem produtos denominados fotoprotetores. Uma vez que os flavonóides são considerados um fator importante de proteção contra a radiação ultravioleta, alguns estudos concentram-se na avaliação da atividade fotoprotetora que algumas plantas, compostas por flavonóides, possam apresentar. Sendo assim, este trabalho teve como objetivo avaliar a atividade fotoprotetora de extratos das flores e folhas de Achillea millefolium L. através de testes in vitro por espectrofotometria no ultravioleta. Embora a literatura descreva a presença de flavonóides nas flores e folhas de A. millefolium, não foi encontrada atividade fotoprotetora nos extratos testados.
Neo-clerodane diterpenoid, a new metalloprotease snake venom inhibitor from Baccharis trimera (Asteraceae): anti-proteolytic and anti-hemorrhagic properties
(Elsevier B.V., 2004-12-07) Januario, A. H. ; Santos, S. L. ; Marcussi, S. ; Mazzi, IV ; Pietro, RCLR ; Sato, D. N. ; Ellena, J. ; Sampaio, S. V. ; Franca, S. C. ; Soares, A. N. ; Univ Ribeirao Preto ; Universidade de São Paulo (USP) ; Universidade Estadual Paulista (Unesp) ; Instituto Adolfo Lutz (IAL)
Many plants are used in traditional medicine as active agents against various effects induced by snakebite. Few attempts have been made however to identify the nature of plain natural products with anti-ophidian properties. Baccharis trimera (Less) DC (Asteraceae), known in Brazil as carqueja. has been popularly used to treat liver diseases. rheumatism. diabetes, as well as digestive, hepatic and renal disorders. The active component was identified as 7alpha-hydroxy-3,13-clerodadiene-16,15:18,19-diolide, C20H28O5, (clerodane diterpenoid, Bt-CD). We report now the anti-proteolytic and anti-hemorrhagic propenies against snake venoms of a Bt-CD inhibitor from B. trimera. Bt-CD exhibited full inhibition of hemorrhage and proteolytic activity caused by Bothrops snake venoms. The inhibitor was able to neutralize the hemorrhagic, fibrinogenolytic and caseinolytic activities of class P-I and III metalloproteases isolated from B. neuwiedi and B. jararacussu venoms. No inhibition of the coagulant activity was observed. Bt-CD also partially inhibited the edema induced by other crude venoms, metallopronteases, basic and acidic phospholipases A(2). To further elucidate the inhibitory specificity of Bt-CD against metalloproteases isolated from snake venoms, a deeper understanding of its Structure and function is necessary. Furthermore, the potential use of these inhibitors to complement anti-venom as an alternative treatment of snakebite envenomations needs to be evaluated in future Studies. (C) 2004 Elsevier B.V.. All rights reserved.
Acesso Aberto
Development and validation of an UV spectrophotometric method for determination of gatifloxacin in tablets
(2005-04-01) Salgado, Hérida Regina Nunes ; Oliveira, C. L. C. G. ; Universidade Estadual Paulista (Unesp)
A simple, sensitive and accurate spectrophotometric method was developed for the assay of gatifloxacin in raw material and tablets. Validation of the method yielded good results concerning range, linearity, precision and accuracy. The absorbance was measured at 287 nm for gatifloxacin tablet solutions. The linearity range was found to be 4.0-14.0 μg/mL for gatifloxacin. It was also found that the excipients in the commercial tablets did not interfere with the method.
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Role of the clinical pharmacist in detection of drug therapy problemas in critically impatients: experience report
(2014) Alves, Gabrielle Mari Rosetti ; Varallo, Fabiana Rossi ; Lucchetta, Rosa Camila ; Mastroianni, Patricia de Carvalho ; Universidade Estadual Paulista (Unesp) ; Universidade Federal do Paraná (UFPR)
This is an experience report on clinical pharmacy in New York, United States of America, in a teaching hospital, describing the results of drug therapy monitoring in critically ill patients, as well as interventions to solve or prevent identified drug therapy problems. The cross-sectional study was conducted by the clinical staff at the Surgical Intensive Care Unit during August 20th to 24th, 2012. Blood counts, serum levels of certain antibiotics, microbiological cultures and their antibiotic susceptibility, possible drug interactions, dosage of each drug prescribed and the compatibility between the route of administration and pharmaceutical form were assessed daily through review of electronic medical records. Twenty seven patients were followed up and 16 drug therapy problems were identified: Unnecessary drug therapy (seven), adverse drug reaction (four), needs additional drug therapy (two), noncompliance (two) and dosage too low (one). After evaluation, the drug therapy problems and their pharmaceutical interventions were reported to clinical pharmaceutical responsible for the Surgical ICU, as well as the multidisciplinary team. Further, the clinical outcomes were monitored and interventions were classified as to its acceptance. Data demonstrate that clinical pharmacists can contribute to the security and proper use of medications, as the trigger tools for intensive monitoring helps in early detection of drug therapy problems and patient safety.