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Encapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopy

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dc.contributor.authorMartins, Murillo L. [UNESP]
dc.contributor.authorOrecchini, Andrea
dc.contributor.authorAguilera, Luis
dc.contributor.authorEckert, Juergen
dc.contributor.authorEmbs, Jan
dc.contributor.authorMatic, Aleksander
dc.contributor.authorSaeki, Margarida Juri [UNESP]
dc.contributor.authorBordallo, Heloisa N.
dc.contributor.authorFrick, B.
dc.contributor.authorKoza, M. M.
dc.contributor.authorBoehm, M.
dc.contributor.authorMutka, H.
dc.contributor.institutionUniv Copenhagen
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Max Von Laue Paul Langevin
dc.contributor.institutionUniv Perugia
dc.contributor.institutionChalmers
dc.contributor.institutionUniv S Florida
dc.contributor.institutionPaul Scherrer Inst
dc.date.accessioned2015-10-21T13:11:56Z
dc.date.available2015-10-21T13:11:56Z
dc.date.issued2015-01-01
dc.description.abstractThe anticancer drug paclitaxel was encapsulated into a bio-nanocomposite formed by magnetic nanoparticles, chitosan and apatite. The aim of this drug carrier is to provide a new perspective against breast cancer. The dynamics of the pure and encapsulated drug were investigated in order to verify possible molecular changes caused by the encapsulation, as well as to follow which interactions may occur between paclitaxel and the composite. Fourier transformed infrared spectroscopy, thermal analysis, inelastic and quasi-elastic neutron scattering experiments were performed. These very preliminary results suggest the successful encapsulation of the drug.en
dc.description.affiliationUniv Copenhagen, Niels Bohr Inst, DK-2100 Copenhagen, Denmark
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationInst Max Von Laue Paul Langevin, F-38042 Grenoble, France
dc.description.affiliationUniv Perugia, Dipartimento Fis, I-06123 Perugia, Italy
dc.description.affiliationChalmers, Dept Appl Phys, S-41296 Gothenburg, Sweden
dc.description.affiliationUniv S Florida, Dept Chem, Tampa, FL 33620 USA
dc.description.affiliationPaul Scherrer Inst, Neutron Scattering Lab, CH-5232 Villigen, Switzerland
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Departamento de Química e Bioquímica, BR-18618970 Botucatu, SP, Brazil
dc.format.extent1-5
dc.identifierhttp://www.epj-conferences.org/articles/epjconf/abs/2015/02/epjconf-Qens-Wins2014_02011/epjconf-Qens-Wins2014_02011.html
dc.identifier.citationQens/wins 2014 - 11th International Conference On Quasielastic Neutron Scattering And 6th International Workshop On Inelastic Neutron Spectrometers. Cedex A: E D P Sciences, v. 83, 5 p., 2015.
dc.identifier.doi10.1051/epjconf/20158302011
dc.identifier.fileWOS000351844900013.pdf
dc.identifier.issn2100-014X
dc.identifier.lattes1802982806436894
dc.identifier.urihttp://hdl.handle.net/11449/128654
dc.identifier.wosWOS:000351844900013
dc.language.isoeng
dc.publisherE D P Sciences
dc.relation.ispartofQens/wins 2014 - 11th International Conference On Quasielastic Neutron Scattering And 6th International Workshop On Inelastic Neutron Spectrometers
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.titleEncapsulation of paclitaxel into a bio-nanocomposite. a study combining inelastic neutron scattering to thermal analysis and infrared spectroscopyen
dc.typeTrabalho apresentado em evento
dcterms.rightsHolderE D P Sciences
dspace.entity.typePublication
unesp.author.lattes1802982806436894
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentQuímica e Bioquímica - IBBpt

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