Antibacterial activity of a stearic acid derivative from Stemodia foliosa
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Resumo
From the hexane-soluble fraction of an ethanol extract from leaves and stems of Stemodia foliosa (Scrophulariaceae), the new stearic acid 4-[(n-pentoxy)phenethyl] ester (1) was isolated. This compound exhibited antibacterial properties at 10μg/mL concentration by using disc diffusion method against Gram-positive bacteria Bacillus cereus and Bacillus subtilis and fast-acid bacterium Mycobacterium fortuitum. The structure of the new compound was elucidated by spectroscopic methods and by chemical conversion.
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4 [(n pentoxy)phenethyl] ester , alcohol , clarithromycin , ester , hexane , plant extract , stearic acid derivative , unclassified drug , acid fast bacterium , antibacterial activity , Bacillus subtilis , controlled study , Gram positive bacterium , Mycobacterium fortuitum , nuclear magnetic resonance spectroscopy , plant leaf , plant stem , Scrophulariaceae , Anti-Bacterial Agents , Bacteria , Clarithromycin , Magnetic Resonance Spectroscopy , Molecular Structure , Plant Extracts , Plant Leaves , Plant Stems , Stearates , Stearic Acids , Actinobacteria (class) , Bacillus cereus , Bacteria (microorganisms) , Mycobacterium , Posibacteria , Stemodia , uncultured actinomycete
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Planta Medica, v. 68, n. 12, p. 1137-1139, 2002.
