EFEITO DE SURFACTANTES NA ESTABILIDADE DE COMPOSTOS DE USO TERAPEUTICO
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A critical revision of literature as regards to the drug stability in the presence of surfactants were realized. The functional groups envolved in the drug decomposition were used to the development of the discussion. The analysis indicated that the detergent effect can be used to control the rates and mechanisms of drug decomposition and to obtain specific information about the drug reactivity in the environment of pharmacological action.
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acetylsalicylic acid amide ampicillin antiinfective agent benzocaine benzodiazepine derivative beta lactam antibiotic bile salt carboxylic acid derivative cephalosporin derivative cetrimide cetylpyridinium salt chloramphenicol chlordiazepoxide chlorpromazine clonazepam clopenthixol diazepam diethazine dodecyl sulfate sodium dodecyltrimethylammonium chloride drug metabolite ester flupentixol functional group homatropine indometacin methylprednisolone oxazepam penicillin derivative penicillin g phenothiazine derivative procaine propicillin prostacyclin salicylic acid derivative surfactant tetracaine unclassified drug catalysis drug degradation drug stability hydrolysis micelle phototoxicity reaction analysis
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Português
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Revista de Ciencias Farmaceuticas, v. 12, p. 183-197.
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