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Mechanism of calcium hydroxide-induced neutrophil migration into air-pouch cavity

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dc.contributor.authorTeixeira de Moraes Costa, Mariana Machado [UNESP]
dc.contributor.authorOliveira, Sandra Helena Penha de [UNESP]
dc.contributor.authorGomes-Filho, Joao Eduardo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2013-09-30T18:29:10Z
dc.date.accessioned2014-05-20T13:43:01Z
dc.date.available2013-09-30T18:29:10Z
dc.date.available2014-05-20T13:43:01Z
dc.date.issued2008-06-01
dc.description.abstractThe aim of this study was to investigate cellular migration induced by calcium hydroxide to air-pouch cavities in mice. The migration was more specific to neutrophil and was dose and time dependent (peaking 96 h after stimulation). This migration was inhibited by pretreatment with thalidomide, indomethacin, MK886, meloxicam, dexamethasone, MK886 associated with indomethacin, and MK886 associated with indomethacin and dexamethasone. The air-pouch exudate from animals stimulated with calcium hydroxide showed an increase of leukotriene-B4 (LTB4), interleukin-1 beta, tumor necrosis factor alpha (TNF-alpha), cytokine-induced neutrophil chemoattractant (KC), and macrophage inflammatory protein 2 (MIP-2) release. Pretreatment with 3% thioglycollate increased the macrophage population in the air pouch but did not change neutrophil migration. Depleting the resident mast cells through chronic pretreatment with compound 48/80 did not alter neutrophil migration in response to calcium hydroxide. It was possible to conclude that calcium hydroxide-induced neutrophil migration to the air-pouch cavity in mice is mediated by LTB4, TNF-alpha, KC, MIP-2, and prostaglandins, but it was not dependent on macrophages or mast cells.en
dc.description.affiliationSão Paulo State Univ, Sch Dent, Dept Pediat Dent, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Sch Dent, Dept Basic Sci, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationSão Paulo State Univ, Sch Dent, Dept Restorat Dent, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Dent, Dept Pediat Dent, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Dent, Dept Basic Sci, BR-16015050 Aracatuba, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, Sch Dent, Dept Restorat Dent, BR-16015050 Aracatuba, SP, Brazil
dc.format.extent814-821
dc.identifierhttp://dx.doi.org/10.1016/j.tripleo.2007.12.013
dc.identifier.citationOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology. New York: Mosby-elsevier, v. 105, n. 6, p. 814-821, 2008.
dc.identifier.doi10.1016/j.tripleo.2007.12.013
dc.identifier.issn1079-2104
dc.identifier.urihttp://hdl.handle.net/11449/14965
dc.identifier.wosWOS:000256261800025
dc.language.isoeng
dc.publisherMosby-elsevier
dc.relation.ispartofOral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleMechanism of calcium hydroxide-induced neutrophil migration into air-pouch cavityen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderMosby-elsevier
dspace.entity.typePublication
unesp.author.orcid0000-0001-5994-2287[3]
unesp.author.orcid0000-0003-0805-1120[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araçatubapt
unesp.departmentCiências Básicas - FOApt
unesp.departmentOdontologia Infantil e Social - FOApt
unesp.departmentOdontologia Restauradora - FOApt

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Araçatuba - FOA - Faculdade de Odontologia