Isolation of ergosterol peroxide and its reversion to ergosterol in the pathogenic fungus Sporothrix schenckii
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Undergraduate course
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Springer Nature
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Article
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Acesso restrito
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Abstract
Ergosterol peroxide, a presumed product of the H2O2-dependent enzymatic oxidation of ergosterol, has been isolated from yeast from yeast forms of the pathogenic fungus Sporothrix schenckii. The substance, which may have a role in fungal virulence, has been characterized mainly using spectroscopic methods (1H and 13C nuclear magnetic resonance and high resolution mass spectra). The purified compound showed a molecular formula of C28H44O3, displaying characteristic features of epidioxy sterols and was reverted to ergosterol when submitted to S. schenckii enzymatic extract.
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Keywords
Epidioxy sterol , Reactive oxygen species , Sporothrix schenckii , antineoplastic agent , drug derivative , ergosterol , ergosterol 5,8 peroxide , ergosterol-5,8-peroxide , chemistry , isolation and purification , metabolism , nuclear magnetic resonance spectroscopy , Sporothrix , thin layer chromatography , Antineoplastic Agents , Chromatography, Thin Layer , Ergosterol , Magnetic Resonance Spectroscopy , Fungi
Language
English
Citation
Mycopathologia, v. 139, n. 1, p. 9-14, 1997.
