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Bed nucleus of the stria terminalis and the cardiovascular responses to chemoreflex activation

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dc.contributor.authorGranjeiro, Erica M.
dc.contributor.authorGomes, Felipe V.
dc.contributor.authorAlves, Fernando H. F.
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.authorCorrea, Fernando M. A.
dc.contributor.authorResstel, Leonardo B. M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:25:37Z
dc.date.available2014-05-20T13:25:37Z
dc.date.issued2012-04-03
dc.description.abstractSeveral studies from our group have indicated that the BNST play an important role in baroreflex modulation. However, the involvement of the BNST in the chemoreflex activity is unknown. Thus, in the present study, we investigated the effect of the local bed nucleus of stria terminalis (BNST) neurotransmission inhibition by bilateral microinjections of the non-selective synaptic blocker cobalt chloride (CoCl2) on the cardiovascular responses to chemoreflex activation in rats. For this purpose, chemoreflex was activated with KCN (i.v.) before and after microinjections of CoCl2 into the BNST. Reversible BNST inactivation produced no significant changes in the magnitude and durations of both pressor and bradycardic responses to intravenous KCN infusion. These findings suggesting that BNST neurotransmission have not influence on both sympathoexcitatory and parasympathoexcitatory components of the peripheral chemoreflex activation. (C) 2012 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Dept Pharmacol, Sch Med Ribeirao Preto, BR-14090090 Ribeirao Preto, SP, Brazil
dc.description.affiliationUniv São Paulo, Dept Physiol, Sch Med Ribeirao Preto, BR-14090090 Ribeirao Preto, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Nat Act Principles & Toxicol, Sch Pharmaceut Sci Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Nat Act Principles & Toxicol, Sch Pharmaceut Sci Araraquara, BR-14801902 Araraquara, SP, Brazil
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdFAPESP: 10/17343-0
dc.description.sponsorshipIdFAPESP: 09/03187-9
dc.description.sponsorshipIdCNPq: 480550/2007-7
dc.description.sponsorshipIdCNPq: 305996/2008-8
dc.format.extent21-26
dc.identifierhttp://dx.doi.org/10.1016/j.autneu.2011.11.004
dc.identifier.citationAutonomic Neuroscience-basic & Clinical. Amsterdam: Elsevier B.V., v. 167, n. 1-2, p. 21-26, 2012.
dc.identifier.doi10.1016/j.autneu.2011.11.004
dc.identifier.fileWOS000301947900005.pdf
dc.identifier.issn1566-0702
dc.identifier.lattes1117432571971568
dc.identifier.urihttp://hdl.handle.net/11449/8135
dc.identifier.wosWOS:000301947900005
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAutonomic Neuroscience-basic & Clinical
dc.relation.ispartofjcr2.605
dc.relation.ispartofsjr0,902
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.subjectAutonomic nervous systemen
dc.subjectCoCl2en
dc.subjectKCNen
dc.subjectCardiovascular systemen
dc.subjectBlood pressureen
dc.subjectHeart rateen
dc.titleBed nucleus of the stria terminalis and the cardiovascular responses to chemoreflex activationen
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes1117432571971568[4]
unesp.author.orcid0000-0002-1942-858X[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas