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Inhibin B and ovarian function after total abdominal hysterectomy in women of reproductive age

dc.contributor.authorNahás, E. [UNESP]
dc.contributor.authorPontes, Anaglória [UNESP]
dc.contributor.authorTraiman, Paulo [UNESP]
dc.contributor.authorNahas Neto, Jorge [UNESP]
dc.contributor.authorDalben, Ivete [UNESP]
dc.contributor.authorDe Luca, L. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:20:38Z
dc.date.available2014-05-27T11:20:38Z
dc.date.issued2003-04-01
dc.description.abstractThe aim of this prospective study was to assess ovarian function using clinical and endocrine parameters in women of reproductive age who underwent total abdominal hysterectomy. Sixty-one women, aged ≤ 40 years, were allocated into two groups: group 1, consisting of 31 patients who had hysterectomy, and group 2, consisting of 30 normal women. Inclusion criteria were normal ovarian function at baseline, normal body weight, no hormonal diseases and basal follicle stimulating hormone (FSH) level of < 15 mIU/ml. FSH, luteinizing hormone (LH), estradiol and inhibin B levels as well as maturation value (MV) were measured by vaginal cytology on three occasions: baseline, and 6 and 12 months after hysterectomy. Analysis of variance, the Friedman test, Mann-Whitney test and t-test statistics were employed to compare the two groups. At baseline the groups were homogeneous. At months 6 and 12, hysterectomized women showed decreased median values of inhibin B, increased median values of estradiol (p < 0.05), unchanged median values of FSH and LH, and decreased median values of MV (p < 0.05). In the hysterectomy group, 12.9% (4/31) of the patients had FSH levels of > 40 mIU/ml, estradiol of < 20 pg/ml and inhibin B of < 5 ng/ml, compatible with ovarian failure. In the control group, all the parameters studied remained unchanged. These results suggest that total abdominal hysterectomy accelerates the decline in ovarian function in women of reproductive age.en
dc.description.affiliationDept. of Gynecology and Obstetrics Botucatu Medical School São Paulo State University, São Paulo
dc.description.affiliationDepartment of Public Health Botucatu Medical School São Paulo State University, São Paulo
dc.description.affiliationDept. of Gynecology and Obstetrics Botucatu Medical School São Paulo State University, Rubiao Junior, Botucatu, Sao Paulo
dc.description.affiliationUnespDept. of Gynecology and Obstetrics Botucatu Medical School São Paulo State University, São Paulo
dc.description.affiliationUnespDepartment of Public Health Botucatu Medical School São Paulo State University, São Paulo
dc.description.affiliationUnespDept. of Gynecology and Obstetrics Botucatu Medical School São Paulo State University, Rubiao Junior, Botucatu, Sao Paulo
dc.format.extent125-131
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/12737673
dc.identifier.citationGynecological Endocrinology, v. 17, n. 2, p. 125-131, 2003.
dc.identifier.issn0951-3590
dc.identifier.lattes0514178654667684
dc.identifier.lattes8334785337106990
dc.identifier.scopus2-s2.0-0037395763
dc.identifier.urihttp://hdl.handle.net/11449/67257
dc.identifier.wosWOS:000182323200006
dc.language.isoeng
dc.relation.ispartofGynecological Endocrinology
dc.relation.ispartofjcr1.453
dc.relation.ispartofsjr0,649
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectHysterectomy
dc.subjectInhibin B
dc.subjectOvarian Function
dc.subjectVaginal Cytology
dc.subjectestradiol
dc.subjectfollitropin
dc.subjectinhibin B
dc.subjectluteinizing hormone
dc.subjectabdominal hysterectomy
dc.subjectadult
dc.subjectanalysis of variance
dc.subjectbody weight
dc.subjectcontrolled study
dc.subjectendocrine function
dc.subjectfemale
dc.subjectFriedman test
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmaturation
dc.subjectovary function
dc.subjectpriority journal
dc.subjectprospective study
dc.subjectrank sum test
dc.subjectreproduction
dc.subjectvagina cytology
dc.subjectAdult
dc.subjectAnalysis of Variance
dc.subjectCase-Control Studies
dc.subjectEstradiol
dc.subjectFemale
dc.subjectFollicle Stimulating Hormone
dc.subjectHumans
dc.subjectInhibins
dc.subjectLongitudinal Studies
dc.subjectLuteinizing Hormone
dc.subjectOvary
dc.subjectProspective Studies
dc.titleInhibin B and ovarian function after total abdominal hysterectomy in women of reproductive ageen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes0514178654667684
unesp.author.lattes8334785337106990
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentGinecologia e Obstetrícia - FMBpt
unesp.departmentSaúde Pública - FMBpt

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