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Publicação:
Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment

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dc.contributor.authorMorise, B. T. [UNESP]
dc.contributor.authorChagas, A. L.D. [UNESP]
dc.contributor.authorBarros, N. R. [UNESP]
dc.contributor.authorMiranda, M. C.R. [UNESP]
dc.contributor.authorBorges, F. A. [UNESP]
dc.contributor.authorGemeinder, J. L.P. [UNESP]
dc.contributor.authorSilva, R. G. [UNESP]
dc.contributor.authorPaulino, C. G. [UNESP]
dc.contributor.authorHerculano, R. D. [UNESP]
dc.contributor.authorNorberto, A. M.Q.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2019-10-06T15:21:00Z
dc.date.available2019-10-06T15:21:00Z
dc.date.issued2019-09-02
dc.description.abstractSialorrhea is characterized by an increase in salivation. One of the adverse reactions of scopolamine is the decrease of salivary volume. Natural rubber latex can be used as a carrier matrix. This study developed and characterized a transdermal drug delivery system using natural rubber latex membranes carried with scopolamine butylbromide, using optical spectroscopy, Infrared spectroscopy, wettability, Scanning Electron Microscopy and hemolytic assays. The kinetic profile of scopolamine butylbromide showed that matrix released 96.49% of the drug and tests showed no hemolytic effects. Physico-chemical characterization and tensile tests showed that this system is a potential alternative for the treatment of sialorrhea.en
dc.description.affiliationSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationInstitute of Chemistry São Paulo State University (UNESP)
dc.description.affiliationFaculty of Medicine São Paulo University (USP)
dc.description.affiliationUnespSchool of Pharmaceutical Sciences São Paulo State University (UNESP)
dc.description.affiliationUnespInstitute of Chemistry São Paulo State University (UNESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIdFAPESP: 2011/17411-8
dc.description.sponsorshipIdFAPESP: PADC 2018/01-I
dc.description.sponsorshipIdCNPq: Process 470261/2012-9
dc.description.sponsorshipIdFAPESP: Processes 2014/17526-8
dc.format.extent788-795
dc.identifierhttp://dx.doi.org/10.1080/00914037.2018.1506984
dc.identifier.citationInternational Journal of Polymeric Materials and Polymeric Biomaterials, v. 68, n. 13, p. 788-795, 2019.
dc.identifier.doi10.1080/00914037.2018.1506984
dc.identifier.issn1563-535X
dc.identifier.issn0091-4037
dc.identifier.scopus2-s2.0-85054878053
dc.identifier.urihttp://hdl.handle.net/11449/186957
dc.language.isoeng
dc.relation.ispartofInternational Journal of Polymeric Materials and Polymeric Biomaterials
dc.rights.accessRightsAcesso abertopt
dc.sourceScopus
dc.subjectbiomaterial
dc.subjectnatural rubber latex
dc.subjectscopolamine
dc.subjectSialorrhea
dc.subjectsustained release
dc.titleScopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatmenten
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.orcid0000-0003-0010-2704[2]
unesp.author.orcid0000-0001-8689-4110[3]
unesp.author.orcid0000-0001-7236-0847[9]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt

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Coleções

Araraquara - FCF - Faculdade de Ciências Farmacêuticas
Araraquara - IQAR - Instituto de Química