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Abo blood groups and helicobacter pylori cagA infection: Evidence of an association

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dc.contributor.authorMattos, D. E. [UNESP]
dc.contributor.authorCintra, J. R.
dc.contributor.authorBrandão de Mattos, C. C.
dc.contributor.authorNakashima, F. [UNESP]
dc.contributor.authorSilva, R. C.M.A.
dc.contributor.authorMoreira, H. W. [UNESP]
dc.contributor.authorde Mattos, L. C.
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionFUNFARME
dc.contributor.institutionFAMERP
dc.date.accessioned2022-04-28T21:00:54Z
dc.date.available2022-04-28T21:00:54Z
dc.date.issued2010-01-01
dc.description.abstractDiseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. Of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.en
dc.description.affiliationClinical Analysis Department School of Pharmaceutical Sciences São Paulo State University UNESP, Araraquara, São Paulo State
dc.description.affiliationRegional Blood Center of São José do Rio Preto Regional Medical School Foundation FUNFARME, São José do Rio Preto, São Paulo State
dc.description.affiliationImmunogenetics Laboratory Molecular Biology Department São José do Rio Preto Medical School FAMERP, São José do Rio Preto, São Paulo State
dc.description.affiliationBiology Department Institute of Biosciences Letters and Exact Sciences São Paulo State University UNESP, São José do Rio Preto, São Paulo State
dc.description.affiliationSpecialized Gastroenterology Laboratory Base Hospital FUNFARME, São José do Rio Preto, São Paulo State
dc.description.affiliationUnespClinical Analysis Department School of Pharmaceutical Sciences São Paulo State University UNESP, Araraquara, São Paulo State
dc.description.affiliationUnespBiology Department Institute of Biosciences Letters and Exact Sciences São Paulo State University UNESP, São José do Rio Preto, São Paulo State
dc.format.extent87-95
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992010005000004
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases, v. 16, n. 1, p. 87-95, 2010.
dc.identifier.doi10.1590/S1678-91992010005000004
dc.identifier.issn1678-9199
dc.identifier.scopus2-s2.0-77950801470
dc.identifier.urihttp://hdl.handle.net/11449/225825
dc.language.isoeng
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.sourceScopus
dc.subjectABO blood groups
dc.subjectCagA strain
dc.subjectChronic active gastritis
dc.subjectH. pylori infection
dc.subjectPeptic ulcers
dc.titleAbo blood groups and helicobacter pylori cagA infection: Evidence of an associationen
dc.typeArtigopt
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentBiologia - IBILCEpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas
São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas