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Publicação:
Amnestic dementia impairment in Parkinson's disease: The role of body composition, ageing and insulin resistance

dc.contributor.authorSchelp, Arthur Oscar [UNESP]
dc.contributor.authorMendes-Chiloff, Cristiane Lara [UNESP]
dc.contributor.authorPaduan, Vanessa Cristina [UNESP]
dc.contributor.authorCorrente, José Eduardo [UNESP]
dc.contributor.authorVieira, Aline [UNESP]
dc.contributor.authorMarchette, Juliana Cristine Nunes [UNESP]
dc.contributor.authorde Souza, Juli Thomaz [UNESP]
dc.contributor.authorLuvizuto, Gustavo José [UNESP]
dc.contributor.authorNogueira, Célia Regina [UNESP]
dc.contributor.authorBazan, Rodrigo [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2018-12-11T17:11:39Z
dc.date.available2018-12-11T17:11:39Z
dc.date.issued2017-08-01
dc.description.abstractBackground The risk of cognitive impairment associated with Parkinson's disease (PD) is related to ageing. The role of body compartmentalization and associated metabolic dysfunctions, as a risk factor for dementia in PD is still not clear. Objective To investigate body mass distribution, insulin resistance, and other parameters in patients without dementia, and those with dementia classified as compromised delayed memory. Subjects and Methods We recorded body composition, basal levels of insulin resistance, and other data from 135 patients, who were followed for at least two years. The patients completed a Brief Cognitive Battery test. Patients with delayed recall memory impairment were assessed using the Mattis dementia rating scale. Results There was a correlation between age and the patient's scores. Age was negatively correlated with scores on all of the screening battery subtests (p ≤ 0.001), while formal education was positively correlated with the test scores. Insulin resistance was higher in non-demented patients compared to patients with impaired memory (p = 0.0027). There was no association between body composition and cognitive dysfunction in patients with PD. Conclusions The results of this study indicate an apparent decrease in insulin resistance associated with cognitive impairment in PD. We found no correlations between body composition and memory dysfunction associated with PD.en
dc.description.affiliationDepartment of Neurology Psychology and Psychiatry Univ Estadual Paulista (UNESP)
dc.description.affiliationPsychology Service Clinical Hospital of Botucatu Medical School
dc.description.affiliationBioscience Institute Statistical Department – Univ Estadual Paulista (UNESP)
dc.description.affiliationNeurology Fellowship Dept. of Neurology Psychology and Psychiatry Univ Estadual Paulista (UNESP)
dc.description.affiliationRehabilitation Service Clinical Hospital of Botucatu Medical School
dc.description.affiliationDepartment of Internal Medicine – Univ Estadual Paulista (UNESP)
dc.description.affiliationUnespDepartment of Neurology Psychology and Psychiatry Univ Estadual Paulista (UNESP)
dc.description.affiliationUnespPsychology Service Clinical Hospital of Botucatu Medical School
dc.description.affiliationUnespBioscience Institute Statistical Department – Univ Estadual Paulista (UNESP)
dc.description.affiliationUnespNeurology Fellowship Dept. of Neurology Psychology and Psychiatry Univ Estadual Paulista (UNESP)
dc.description.affiliationUnespRehabilitation Service Clinical Hospital of Botucatu Medical School
dc.description.affiliationUnespDepartment of Internal Medicine – Univ Estadual Paulista (UNESP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012–11394-7
dc.format.extent47-51
dc.identifierhttp://dx.doi.org/10.1016/j.clnesp.2017.03.006
dc.identifier.citationClinical Nutrition ESPEN, v. 20, p. 47-51.
dc.identifier.doi10.1016/j.clnesp.2017.03.006
dc.identifier.issn2405-4577
dc.identifier.scopus2-s2.0-85018989830
dc.identifier.urihttp://hdl.handle.net/11449/174547
dc.language.isoeng
dc.relation.ispartofClinical Nutrition ESPEN
dc.relation.ispartofsjr0,245
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAgeing
dc.subjectBody composition
dc.subjectDementia
dc.subjectInsulin resistance
dc.subjectParkinson's disease
dc.titleAmnestic dementia impairment in Parkinson's disease: The role of body composition, ageing and insulin resistanceen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes5248388716505709[1]
unesp.author.lattes7607038776901890[9]
unesp.author.orcid0000-0001-6425-0058[6]
unesp.author.orcid0000-0002-4014-0660[9]
unesp.author.orcid0000-0001-5928-7497[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentClínica Médica - FMBpt
unesp.departmentNeurologia, Psicologia e Psiquiatria - FMBpt

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