Publication: Morphological alterations of epidermis of rabbits infested by R. sanguineus ticks and exposed to Selamectin (active principle of Pfizer Revolution (R) acaricide): A confocal microscopy study
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Undergraduate course
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Publisher
Elsevier B.V.
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Article
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Abstract
The present study analyzed, by means of confocal laser scanning microscopy, the epidermis of rabbits infested by the brown dog tick Rhipicephalus sanguineus and exposed to concentrations of 50%, 80% and 100% of a selamectin-based commercial acaricide (Pfizer's Revolution (R)). The results demonstrated that rabbits exposed to concentrations of 80% and 100% of the Revolution acaricide, which contains 12% selamectin, showed thinning of epithelial tissue of the epidermis with associated cellular disorganization. Individuals exposed to a 50% concentration showed lower epidermal tissue disorganization when compared to those exposed to the higher doses of the acaricide (80% and 100%). Whereas selamectin, when used in higher concentrations (80% and 100% Revolution) can alter the morphology of the epidermis, at lower concentrations (50%), even though still able to eliminate ectoparasites, it causes less toxicity damage to the host. Selamectin can be considered a dose-dependent toxic agent, since higher concentrations increase the morphological changes in the epidermis of the host rabbits. (C) 2013 Elsevier GmbH. All rights reserved.
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Keywords
Epidermis, Selamectin, Acanthosis, Pathology, Toxicology, Ticks, Rabbit
Language
English
Citation
Acta Histochemica. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 116, n. 3, p. 534-538, 2014.
