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Tuberculosis diagnosis after bleach processing for early stage tuberculosis laboratory capacity building

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dc.contributor.authorDavid, S.
dc.contributor.authorSutre, A. F.
dc.contributor.authorSanca, A.
dc.contributor.authorMane, A.
dc.contributor.authorHenriques, V.
dc.contributor.authorPortugal, C.
dc.contributor.authorSancho, L.
dc.contributor.authorCardoso, A.
dc.contributor.authorPaixao, E.
dc.contributor.authorDuarte, E. L.
dc.contributor.authorLeite, Clarice Queico Fujimura [UNESP]
dc.contributor.authorSalem, J. I.
dc.contributor.authorAntunes, A.
dc.contributor.institutionInst Nacl Saúde Dr Ricardo Jorge INSA
dc.contributor.institutionCumura Hosp
dc.contributor.institutionHosp Fernando Fonseca
dc.contributor.institutionUniv Evora
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInst Nacl de Pesquisas da Amazonia
dc.contributor.institutionUniv Nova Lisboa
dc.date.accessioned2014-05-20T15:33:24Z
dc.date.available2014-05-20T15:33:24Z
dc.date.issued2012-11-01
dc.description.abstractThe diagnosis of tuberculosis is seriously hampered in the absence of standard biosafety laboratory facilities for specimen concentration and Mycobacterium tuberculosis culture. Within a laboratory twinning arrangement, heat-fixed direct smear and sediment from 74 bleach-processed and 20 non-processed specimens from Cumura Hospital, Guinea-Bissau, were sent to Lisbon for molecular evaluation of rifampicin resistance. Sequence analysis of a 369 base-pair ppoB locus detected 3.2% (3/94) resistant specimens. To our knowledge, this represents the first report on the molecular analysis of M. tuberculosis from bleach-processed sputum, an alternative to current diagnostic practice in low-resource settings.en
dc.description.affiliationInst Nacl Saúde Dr Ricardo Jorge INSA, IP, P-1649016 Lisbon, Portugal
dc.description.affiliationCumura Hosp, Cumura, Guinea Bissau
dc.description.affiliationHosp Fernando Fonseca, Serv Patol Clin, Amadora, Portugal
dc.description.affiliationUniv Evora, Inst Ciencias Agrarias & Ambientais Mediterran, Escola Ciencias & Tecnol, Evora, Portugal
dc.description.affiliationUniv Estadual Paulista, Fac Pharmaceut Sci, São Paulo, Brazil
dc.description.affiliationInst Nacl de Pesquisas da Amazonia, Manaus, Amazonas, Brazil
dc.description.affiliationUniv Nova Lisboa, IHMT, P-1200 Lisbon, Portugal
dc.description.affiliationUnespUniv Estadual Paulista, Fac Pharmaceut Sci, São Paulo, Brazil
dc.description.sponsorshipLuso-American Development Foundation (LACR Award program)
dc.format.extent1535-1537
dc.identifierhttp://dx.doi.org/10.5588/ijtld.11.0658
dc.identifier.citationInternational Journal of Tuberculosis and Lung Disease. Paris: Int Union Against Tuberculosis Lung Disease (i U A T L D), v. 16, n. 11, p. 1535-1537, 2012.
dc.identifier.doi10.5588/ijtld.11.0658
dc.identifier.issn1027-3719
dc.identifier.lattes2114570774349859
dc.identifier.urihttp://hdl.handle.net/11449/42034
dc.identifier.wosWOS:000310173900020
dc.language.isoeng
dc.publisherInt Union Against Tuberculosis Lung Disease (i U A T L D)
dc.relation.ispartofInternational Journal of Tuberculosis and Lung Disease
dc.relation.ispartofjcr2.392
dc.relation.ispartofsjr1,533
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.subjectMycobacterium tuberculosisen
dc.subjectrpoBen
dc.subjectsputum smear microscopyen
dc.subjectsodium hypochloriteen
dc.subjectdenaturing high-performance liquid chromatography (DHPLC) sequencingen
dc.titleTuberculosis diagnosis after bleach processing for early stage tuberculosis laboratory capacity buildingen
dc.typeArtigopt
dcterms.licensehttp://www.theunion.org/index.php/en/journals/the-Journal/information-for-authors-/institutional-repository-policy
dcterms.rightsHolderInt Union Against Tuberculosis Lung Disease (i U A T L D)
dspace.entity.typePublication
relation.isDepartmentOfPublication5004bcab-94af-4939-b980-091ae9d0a19e
relation.isDepartmentOfPublication.latestForDiscovery5004bcab-94af-4939-b980-091ae9d0a19e
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes2114570774349859
unesp.author.orcid0000-0001-6483-8660[1]
unesp.author.orcid0000-0003-0589-3533[10]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentCiências Biológicas - FCFpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas