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ABO blood groups and Helicobacter pylori cagA infection: evidence of an association

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dc.contributor.authorMattos, D. E. [UNESP]
dc.contributor.authorCintra, J. R.
dc.contributor.authorBrandao de Mattos, C. C.
dc.contributor.authorNakashima, F. [UNESP]
dc.contributor.authorSilva, R. C. M. A.
dc.contributor.authorMoreira, Haroldo Wilson [UNESP]
dc.contributor.authorde Mattos, L. C.
dc.contributor.institutionFaculdade de Medicina de São José do Rio Preto (FAMERP)
dc.contributor.institutionFUNFARME
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:00:54Z
dc.date.available2014-05-20T14:00:54Z
dc.date.issued2010-01-01
dc.description.abstractDiseases resulting from Helicobacter pylori infection appear to be dependent on a host of genetic traits and virulence factors possessed by this microorganism. This paper aimed to investigate the association between the ABO histo-blood groups and H. pylori cagA infections. Genomic DNA samples (n = 110) of gastric biopsies obtained from patients with endoscopic diagnosis of peptic ulcers (n = 25) and chronic active gastritis (n = 85) were analyzed by PCR using specific primers for the cagA gene. of the samples, 66.4% (n = 73) tested positive and 33.6% (n = 37) negative for the gene. The cagA strain was predominant in peptic ulcers (n = 21; 84.0%) compared with chronic active gastritis (n = 52; 61.2%) (p = 0.05; OR 3.332; 95% CI: 1.050-10.576). Additionally, the cagA strain was prevalent in the type O blood (48/63; 76.2%) compared with other ABO phenotypes (25/47; 53.2%) (p = 0.01; OR 2.816; 95% CI: 1.246-6.364). These results suggest that H. pylori cagA infection is associated with the O blood group in Brazilian patients suffering from chronic active gastritis and peptic ulcers.en
dc.description.affiliationFaculdade de Medicina de São José do Rio Preto (FAMERP), Dept Biol Mol, Lab Imunogenet, Sao Jose do Rio Preto Med Sch,FAMERP, BR-15090000 Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationFUNFARME, Reg Med Sch Fdn, Reg Blood Ctr Sao Jose do Rio Preto, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Clin Anal Dept, Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Biol, Inst Biosci Letters & Exact Sci, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationFUNFARME, Base Hosp, Specialized Gastroenterol Lab, Sao Jose do Rio Preto, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Clin Anal Dept, Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Biol, Inst Biosci Letters & Exact Sci, Sao Jose do Rio Preto, SP, Brazil
dc.description.sponsorshipBAP/FAMERP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdBAP/FAMERP: 4291/2007
dc.format.extent87-95
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992010005000004
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases. Botucatu: Cevap-unesp, v. 16, n. 1, p. 87-95, 2010.
dc.identifier.fileS1678-91992010000100009-en.pdf
dc.identifier.issn1678-9199
dc.identifier.lattes9424175688206545
dc.identifier.scieloS1678-91992010000100009
dc.identifier.urihttp://hdl.handle.net/11449/21514
dc.identifier.wosWOS:000276086200009
dc.language.isoeng
dc.publisherUniversidade Estadual Paulista (Unesp), Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP)
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.relation.ispartofjcr1.782
dc.relation.ispartofsjr0,573
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.subjectABO blood groupsen
dc.subjectH. pylori infectionen
dc.subjectcagA strainen
dc.subjectchronic active gastritisen
dc.subjectpeptic ulcersen
dc.titleABO blood groups and Helicobacter pylori cagA infection: evidence of an associationen
dc.typeArtigopt
dcterms.licensehttp://www.scielo.br/revistas/jvatitd/iaboutj.htm
dcterms.rightsHolderCevap-unesp
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes9424175688206545
unesp.author.orcid0000-0002-4836-3113[3]
unesp.author.orcid0000-0002-8572-8177[7]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências Letras e Ciências Exatas, São José do Rio Pretopt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentBiologia - IBILCEpt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas
São José do Rio Preto - IBILCE - Instituto de Biociências, Letras e Ciências Exatas