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Surface-enhanced Raman scattering (SERS) applied to cancer diagnosis and detection of pesticides, explosives, and drugs

dc.contributor.authorAoki, Pedro H.B. [UNESP]
dc.contributor.authorFurini, Leonardo N. [UNESP]
dc.contributor.authorAlessio, Priscila [UNESP]
dc.contributor.authorAliaga, Alvaro E. [UNESP]
dc.contributor.authorConstantino, Carlos J.L. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:28:21Z
dc.date.available2014-05-27T11:28:21Z
dc.date.issued2013-02-01
dc.description.abstractThe inelastic scattering of light, Raman scattering, presents a very low cross section. However, the signal can be amplified by several orders of magnitude, leading to the so-called surface-enhanced Raman scattering (SERS) phenomenon. Basically, the SERS effect is achieved when the target molecule (analyte) is adsorbed onto metallic nanoparticles, usually noble metals. This article presents an overview of the applications of SERS to cancer diagnosis and the detection of pesticides, explosives, and drugs (illicit and pharmacological). SERS is routinely applied nowadays to detect and identify analytes at very low concentrations, including for single-molecule detection. However, the application of SERS as an analytical tool requires reliable and reproducible SERS substrates, in terms of enhancement factors, which depends on the size, shape, and aggregation of the metallic nanoparticles. Therefore, the production of reliable and reproducible SERS substrates is a challenge in the field. Besides, the metallic nanoparticles can also induce changes in the system by possible interactions with the analyte under investigation, which must be taken into account. This review will present work in which, under certain specific experimental conditions, SERS has been analytically applied.en
dc.description.affiliationFaculdade de Ciencias E Tecnologia UNESP - Universidade Estadual Paulista, Presidente Prudente, SP 19060-900
dc.description.affiliationUnespFaculdade de Ciencias E Tecnologia UNESP - Universidade Estadual Paulista, Presidente Prudente, SP 19060-900
dc.format.extent55-76
dc.identifierhttp://dx.doi.org/10.1515/revac-2012-0019
dc.identifier.citationReviews in Analytical Chemistry, v. 32, n. 1, p. 55-76, 2013.
dc.identifier.doi10.1515/revac-2012-0019
dc.identifier.issn0793-0135
dc.identifier.lattes7384168674539702
dc.identifier.lattes9727122203219263
dc.identifier.orcid0000-0003-4701-6408
dc.identifier.orcid0000-0002-1345-0540
dc.identifier.scopus2-s2.0-84877971634
dc.identifier.urihttp://hdl.handle.net/11449/74533
dc.identifier.wosWOS:000318408000004
dc.language.isoeng
dc.relation.ispartofReviews in Analytical Chemistry
dc.relation.ispartofjcr2.111
dc.relation.ispartofsjr0,505
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectAnalyte detection
dc.subjectRaman
dc.subjectSERS
dc.titleSurface-enhanced Raman scattering (SERS) applied to cancer diagnosis and detection of pesticides, explosives, and drugsen
dc.typeArtigo
dcterms.licensehttp://www.degruyter.com/dg/page/576/repository-policy
dspace.entity.typePublication
unesp.author.lattes7384168674539702[1]
unesp.author.lattes9727122203219263[3]
unesp.author.lattes6118325967319836[5]
unesp.author.orcid0000-0002-1345-0540[3]
unesp.author.orcid0000-0003-4701-6408[1]
unesp.author.orcid0000-0002-5921-3161[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências e Tecnologia, Presidente Prudentept
unesp.departmentFísica, Química e Biologia - FCTpt

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