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Anti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test method

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dc.contributor.authorMantovani, R. P. [UNESP]
dc.contributor.authorRall, V. L.M. [UNESP]
dc.contributor.authorBatalha, J. E.N. [UNESP]
dc.contributor.authorFernandes, A. A.H. [UNESP]
dc.contributor.authorFernandes Jr., Ary [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionInstituto de Biociências
dc.date.accessioned2022-04-28T20:41:59Z
dc.date.available2022-04-28T20:41:59Z
dc.date.issued2008-01-01
dc.description.abstractPropolis is a natural resinous substance collected by bees from vegetal sources and its therapeutic properties have been investigated. In this work, we evaluated the inhibitory activity of ethanolic extracts of propolis (EEP) from the Southeast and South of Brazil on coagulase-negative Staphylococcus (CNS) growth as well as the EEP in vitro synergism with antimicrobial drugs by using the diffusion method (E-test). The EEP chemical characteristics (dry weight, pH, flavonoid and phenolic compounds) were determined. Seven drugs were tested, and synergism was observed between three drugs and Southeast EEP, six drugs and South EEP, and one drug and ethanol control. Ethanolic extracts of propolis from the South of Brazil presented the greatest flavonoid content and synergism rate, while EEP from the Southeast presented the greatest anti-CNS activity and phenolic compound content. Results showed the correlation among anti-CNS activity, synergism rate and chemical characteristics of propolis.en
dc.description.affiliationDepartment of Microbiology and Immunology Botucatu Institute of Biosciences São Paulo State University, Botucatu, São Paulo State
dc.description.affiliationDepartment of Chemistry and Biochemistry IBB UNESP, Botucatu, São Paulo State
dc.description.affiliationDepartamento de Microbiologia e Imunologia Instituto de Biociências Campus de Botucatu, SP
dc.description.affiliationUnespDepartment of Microbiology and Immunology Botucatu Institute of Biosciences São Paulo State University, Botucatu, São Paulo State
dc.description.affiliationUnespDepartment of Chemistry and Biochemistry IBB UNESP, Botucatu, São Paulo State
dc.format.extent357-365
dc.identifierhttp://dx.doi.org/10.1590/S1678-91992008000200012
dc.identifier.citationJournal of Venomous Animals and Toxins Including Tropical Diseases, v. 14, n. 2, p. 357-365, 2008.
dc.identifier.doi10.1590/S1678-91992008000200012
dc.identifier.issn1678-9199
dc.identifier.scopus2-s2.0-45349101030
dc.identifier.urihttp://hdl.handle.net/11449/225184
dc.language.isoeng
dc.relation.ispartofJournal of Venomous Animals and Toxins Including Tropical Diseases
dc.sourceScopus
dc.subjectAntimicrobial drugs
dc.subjectBrazilian propolis
dc.subjectCoagulase-negative Staphylococcus
dc.subjectE-test
dc.subjectSynergism
dc.titleAnti-coagulase-negative Staphylococcus activity of ethanolic extracts of propolis from two Brazilian regions and synergism with antimicrobial drugs by the E-test methoden
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentMicrobiologia e Imunologia - IBBpt
unesp.departmentQuímica e Bioquímica - IBBpt

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