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Role of the bed nucleus of the stria terminalis in cardiovascular changes following chronic treatment with cocaine and testosterone: A role beyond drug seeking in addiction?

dc.contributor.authorCruz, F. C. [UNESP]
dc.contributor.authorAlves, F. H F
dc.contributor.authorLeão, R. M. [UNESP]
dc.contributor.authorPlaneta, Cleopatra da Silva [UNESP]
dc.contributor.authorCrestani, Carlos Cesar [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUS National Institutes of Health, Department of Health and Human Services
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-27T11:30:53Z
dc.date.available2014-05-27T11:30:53Z
dc.date.issued2013-12-03
dc.description.abstractNeural plasticity has been observed in the bed nucleus of the stria terminalis (BNST) following exposure to both cocaine and androgenic-anabolic steroids. Here we investigated the involvement of the BNST on changes in cardiovascular function and baroreflex activity following either single or combined administration of cocaine and testosterone for 10 consecutive days in rats. Single administration of testosterone increased values of arterial pressure, evoked rest bradycardia and reduced baroreflex-mediated bradycardia. These effects of testosterone were not affected by BNST inactivation caused by local bilateral microinjections of the nonselective synaptic blocker CoCl2. The single administration of cocaine as well as the combined treatment with testosterone and cocaine increased both bradycardiac and tachycardiac responses of the baroreflex. Cocaine-evoked baroreflex changes were totally reversed after BNST inactivation. However, BNST inhibition in animals subjected to combined treatment with cocaine and testosterone reversed only the increase in reflex tachycardia, whereas facilitation of reflex bradycardia was not affected by local BNST treatment with CoCl2. In conclusion, the present study provides the first direct evidence that the BNST play a role in cardiovascular changes associated with drug abuse. Our findings suggest that alterations in cardiovascular function following subchronic exposure to cocaine are mediated by neural plasticity in the BNST. The single treatment with cocaine and the combined administration of testosterone and cocaine had similar effects on baroreflex activity, however the association with testosterone inhibited cocaine-induced changes in the BNST control of reflex bradycardia. Testosterone-induced cardiovascular changes seem to be independent of the BNST. © 2013 IBRO.en
dc.description.affiliationLaboratory of Pharmacology, Department of Natural Active Principles and Toxicology School of Pharmaceutical Sciences Univ. Estadual Paulista - UNESP, Araraquara, SP 14801-902
dc.description.affiliationBehavioral Neuroscience Branch, Intramural Research Program National Institute on Drug Abuse US National Institutes of Health, Department of Health and Human Services, Baltimore, MD
dc.description.affiliationDepartment of Pharmacology School of Medicine of Ribeirão Preto University of São Paulo, Ribeirão Preto, SP 14090-090
dc.description.affiliationJoint UFSCar-UNESP Graduate Program in Physiological Sciences
dc.description.affiliationUnespLaboratory of Pharmacology, Department of Natural Active Principles and Toxicology School of Pharmaceutical Sciences Univ. Estadual Paulista - UNESP, Araraquara, SP 14801-902
dc.description.affiliationUnespJoint UFSCar-UNESP Graduate Program in Physiological Sciences
dc.format.extent29-39
dc.identifierhttp://dx.doi.org/10.1016/j.neuroscience.2013.08.034
dc.identifier.citationNeuroscience, v. 253, p. 29-39.
dc.identifier.doi10.1016/j.neuroscience.2013.08.034
dc.identifier.issn0306-4522
dc.identifier.issn1873-7544
dc.identifier.lattes2514762545280942
dc.identifier.lattes1117432571971568
dc.identifier.orcid0000-0002-1378-6327
dc.identifier.scopus2-s2.0-84884571435
dc.identifier.urihttp://hdl.handle.net/11449/76922
dc.identifier.wosWOS:000326997100004
dc.language.isoeng
dc.relation.ispartofNeuroscience
dc.relation.ispartofjcr3.382
dc.relation.ispartofsjr1,602
dc.rights.accessRightsAcesso restritopt
dc.sourceScopus
dc.subjectAddiction
dc.subjectBaroreflex
dc.subjectBNST
dc.subjectCocaine
dc.subjectExtended amygdala
dc.subjectSteroids
dc.titleRole of the bed nucleus of the stria terminalis in cardiovascular changes following chronic treatment with cocaine and testosterone: A role beyond drug seeking in addiction?en
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes1117432571971568[5]
unesp.author.lattes2514762545280942[4]
unesp.author.orcid0000-0002-1942-858X[5]
unesp.author.orcid0000-0002-1378-6327[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentPrincípios Ativos Naturais e Toxicologia - FCFpt

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