Ativação de macrófagos por produtos naturais obtidos da Achillea millefolium L. (Asteraceae)

Lopes, F. C M [UNESP]; Moreira, Raquel Regina Duarte [UNESP]; Carlos, Iracilda Zeppone [UNESP]

Ativação de macrófagos por produtos naturais obtidos da Achillea millefolium L. (Asteraceae)

Data

2003-12-01

Autores

Lopes, F. C M

Moreira, Raquel Regina Duarte

Carlos, Iracilda Zeppone

Tipo

Artigo

Direito de acesso

Acesso restrito

Resumo

Plants are a valuable source of natural products for the maintenance of human health. The purpose of this paper was the study of immunologic activity of yarrow (Achillea millefolium L.), a largely used plant in popular medicine that has many different properties such as: antiinflammatory, astringent, antiseptic and antispasmodic. Macrophages stimulation was evaluated by the determination of H2O2, NO and TNF-α in supernatants of peritoneal macrophages cultures of mice in the presence of the yarrow leaves extract. The thin layer chromatography of extract was also analyzed, showing rutin. All concentrations showed a moderate release of H2O2 and the concentrations of 6, 8 and 10mg/mL had a higher release of NO. The TNF-a was produced in all concentrations, but the best result was obtained at 4mg/mL. Analyzing the results, it is suggested that the yarrow ethanolic extract can modulate the macrophages activation.