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Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P-acnes

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dc.contributor.authorMegid, Jane [UNESP]
dc.contributor.authorKaneno, Ramon [UNESP]
dc.contributor.authorNozaki, C. N.
dc.contributor.authorBrito, CJC
dc.contributor.authorAlmeida, M. F.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionCtr Controle Zoonoses
dc.date.accessioned2014-05-20T13:38:11Z
dc.date.available2014-05-20T13:38:11Z
dc.date.issued2004-11-01
dc.description.abstractMacrophage activity, cytokines serum concentration, serum neutralizing antibodies and lethality by rabies were evaluated in swiss mice experimentally infected with street rabies virus and submitted or not to antirabies vaccination and immunomodulation with P. acnes. Animals were killed at different times and serum was collected in order to evaluate cytokines concentration; peritonial and splenic macrophages were collected for macrophage activity evaluation. Greater survival rates higher IL-10 and low IL-6 serum concentration were observed in vaccinated animals treated using P. acnes. (C) 2004 Elsevier Ltd. All rights reserved.en
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Fac Vet Med, Dept Vet Hyg & Publ Hlth, Botucatu, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Julio Mesquita Filho, Inst Ciências Biol, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.description.affiliationCtr Controle Zoonoses, São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Fac Vet Med, Dept Vet Hyg & Publ Hlth, Botucatu, SP, Brazil
dc.description.affiliationUnespUniv Estadual Paulista Julio Mesquita Filho, Inst Ciências Biol, Dept Microbiol & Immunol, Botucatu, SP, Brazil
dc.format.extent393-411
dc.identifierhttp://dx.doi.org/10.1016/j.cimid.2004.01.002
dc.identifier.citationComparative Immunology Microbiology and Infectious Diseases. Oxford: Pergamon-Elsevier B.V., v. 27, n. 6, p. 393-411, 2004.
dc.identifier.doi10.1016/j.cimid.2004.01.002
dc.identifier.issn0147-9571
dc.identifier.lattes8845835550637809
dc.identifier.orcid0000-0002-4292-3298
dc.identifier.urihttp://hdl.handle.net/11449/13246
dc.identifier.wosWOS:000225054700001
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofComparative Immunology Microbiology and Infectious Diseases
dc.relation.ispartofjcr1.920
dc.relation.ispartofsjr0,877
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectrabiespt
dc.subjectcytokinespt
dc.subjectimmunomodulationpt
dc.subjectvaccinept
dc.subjectmacrophagept
dc.subjectIL-10pt
dc.subjectIL-6pt
dc.titleIncreased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P-acnesen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes8845835550637809[2]
unesp.author.orcid0000-0002-6540-7157[1]
unesp.author.orcid0000-0002-4292-3298[2]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.departmentHigiene Veterinária e Saúde Pública - FMVZpt
unesp.departmentMicrobiologia e Imunologia - IBBpt

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Botucatu - FMVZ - Faculdade de Medicina Veterinária e Zootecnia
Botucatu - IBB - Instituto de Biociências