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Publicação:
Osteogenic potential of mesenchymal cells derived from canine umbilical cord matrix co-cultured with platelet-rich plasma and demineralized bone matrix

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dc.contributor.authorSouza, Talita Floering Brêda [UNESP]
dc.contributor.authorSakamoto, Silmara Sanae [UNESP]
dc.contributor.authorFerreira, Gabriel Thadeu Nogueira Martins [UNESP]
dc.contributor.authorCarvalho, Roberto Gameiro de [UNESP]
dc.contributor.authorMarinho, Márcia [UNESP]
dc.contributor.authorAndrade, Alexandre Lima de [UNESP]
dc.contributor.authorCardoso, Tereza Cristina [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2015-12-07T15:35:25Z
dc.date.available2015-12-07T15:35:25Z
dc.date.issued2015
dc.description.abstractCanine mesenchymal cells (MSCs) derived from Wharton's jelly were co-cultured, then supplemented or not supplemented with platelet rich plasma (PRP) and demineralized bone matrix (DBM) to verify osteogenic differentiation. Osteoblastic differentiation followed by mineralized bone matrix production was found to be significantly higher (p < 0.05) when MSCs were associated with PRP/DBM in culture after 14-21-days of induction. Osteopontin and osteocalcin gene expression were significantly superior (p < 0.05) under the same culture conditions after 21 days of observation. In conclusion, addition of PRP to DBM co-cultured with MSCs successfully induced osteogenesis in vitro.en
dc.description.affiliationLaboratory of Animal Virology and Cell Culture, College of Veterinary Medicine, UNESP-Universidade Estadual Paulista, Aracatuba, SP 16050-680, Brazil.
dc.description.affiliationUnespLaboratory of Animal Virology and Cell Culture, College of Veterinary Medicine, UNESP-Universidade Estadual Paulista, Araçatuba, SP 16050-680, Brazil.
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2010/52465-9
dc.description.sponsorshipIdFAPESP: 2011/50845-1
dc.format.extent381-384
dc.identifierhttp://dx.doi.org/10.4142/jvs.2015.16.3.381
dc.identifier.citationJournal Of Veterinary Science, v. 16, n. 3, p. 381-384, 2015.
dc.identifier.doi10.4142/jvs.2015.16.3.381
dc.identifier.issn1976-555X
dc.identifier.lattes5071093931017493
dc.identifier.lattes6404176495306171
dc.identifier.lattes5431798684243196
dc.identifier.orcid0000-0002-0923-1943
dc.identifier.pmcPMC4588025
dc.identifier.pubmed26040617
dc.identifier.urihttp://hdl.handle.net/11449/131431
dc.language.isoeng
dc.publisherThe Korean Society of Veterinary Science
dc.relation.ispartofJournal Of Veterinary Science
dc.rights.accessRightsAcesso restrito
dc.sourcePubMed
dc.subjectBoneen
dc.subjectMesenchymal stem cellsen
dc.subjectPlatelet-rich plasmaen
dc.subjectUmbilical corden
dc.titleOsteogenic potential of mesenchymal cells derived from canine umbilical cord matrix co-cultured with platelet-rich plasma and demineralized bone matrixen
dc.typeArtigo
dcterms.rightsHolderThe Korean Society of Veterinary Science
dspace.entity.typePublication
unesp.author.lattes5071093931017493
unesp.author.lattes6404176495306171[6]
unesp.author.lattes5431798684243196[4]
unesp.author.orcid0000-0003-2177-6214[5]
unesp.author.orcid0000-0002-0923-1943[4]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária, Araçatubapt
unesp.departmentClínica, Cirurgia e Reprodução Animal - FMVApt
unesp.departmentApoio, Produção e Saúde Animal - FMVApt

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Coleções

Araçatuba - FMVA - Faculdade de Medicina Veterinária