Publicação: LC-DAD Determination of Fleroxacin in Bulk and Pharmaceutical Dosage Forms
dc.contributor.author | Salgado, Hérida Regina Nunes [UNESP] | |
dc.contributor.author | Moreno, Andreia [UNESP] | |
dc.contributor.author | Garg, Sanjay | |
dc.contributor.institution | Univ Auckland | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.date.accessioned | 2014-05-20T15:32:03Z | |
dc.date.available | 2014-05-20T15:32:03Z | |
dc.date.issued | 2009-06-01 | |
dc.description.abstract | Fleroxacin is a third generation fluoroquinolone with broad spectrum antibacterial activity. In this work an LC-DAD method for the analysis of fleroxacin was developed and validated using UV detection at 286 nm. The method was validated for linearity, precision, robustness, LOD, LOQ, specificity and accuracy at concentrations of 0.2-20.0 mu g mL(-1) and r (2) = 1. The LOD and LOQ were 0.059 and 0.197 mu g, respectively, the recoveries were 99.92-102.0% and the CV was less than 2.0%. The LC-DAD validated method provided analytical sensitivity, specificity and reproducibility suitable for quality control analysis. | en |
dc.description.affiliation | Univ Auckland, Dept Pharm, Fac Med & Hlth Sci, Auckland 1, New Zealand | |
dc.description.affiliation | UNESP, Programa Posgrad Ciencias Farmaceut, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | |
dc.description.affiliationUnesp | UNESP, Programa Posgrad Ciencias Farmaceut, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipId | CAPES: 0274/04-6 | |
dc.format.extent | 237-240 | |
dc.identifier | http://dx.doi.org/10.1365/s10337-009-1053-8 | |
dc.identifier.citation | Chromatographia. Wiesbaden: Vieweg, v. 69, p. 237-240, 2009. | |
dc.identifier.doi | 10.1365/s10337-009-1053-8 | |
dc.identifier.issn | 0009-5893 | |
dc.identifier.uri | http://hdl.handle.net/11449/41051 | |
dc.identifier.wos | WOS:000267330400021 | |
dc.language.iso | eng | |
dc.publisher | Vieweg | |
dc.relation.ispartof | Chromatographia | |
dc.relation.ispartofjcr | 1.401 | |
dc.relation.ispartofsjr | 0,514 | |
dc.rights.accessRights | Acesso restrito | pt |
dc.source | Web of Science | |
dc.subject | Column liquid chromatography | en |
dc.subject | Liquid chromatography-diode array detection | en |
dc.subject | Quality control | en |
dc.subject | Fleroxacin | en |
dc.title | LC-DAD Determination of Fleroxacin in Bulk and Pharmaceutical Dosage Forms | en |
dc.type | Artigo | pt |
dcterms.license | http://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0 | |
dcterms.rightsHolder | Vieweg | |
dspace.entity.type | Publication | |
relation.isDepartmentOfPublication | e214da1b-9929-4ae9-b8fd-655e9bfeda4b | |
relation.isDepartmentOfPublication.latestForDiscovery | e214da1b-9929-4ae9-b8fd-655e9bfeda4b | |
relation.isOrgUnitOfPublication | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
relation.isOrgUnitOfPublication.latestForDiscovery | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
unesp.author.orcid | 0000-0002-0385-340X[1] | |
unesp.author.orcid | 0000-0001-7253-2629[3] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Fármacos e Medicamentos - FCF | pt |
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