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The effects of aging on rho-kinase and insulin signaling in skeletal muscle and white adipose tissue of rats

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dc.contributor.authorMuñoz, Vitor Rosetto
dc.contributor.authorGaspar, Rafael Calais
dc.contributor.authorKuga, Gabriel Keine
dc.contributor.authorPavan, Isadora Carolina Betim
dc.contributor.authorSimabuco, Fernando Moreira
dc.contributor.authorDa Silva, Adelino Sanchez Ramos
dc.contributor.authorDe Moura, Leandro Pereira [UNESP]
dc.contributor.authorCintra, Dennys Esper
dc.contributor.authorRopelle, Eduardo Rochete
dc.contributor.authorPauli, José Rodrigo
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2020-12-12T00:57:23Z
dc.date.available2020-12-12T00:57:23Z
dc.date.issued2020-02-14
dc.description.abstractThe insulin receptor substrate 1 regulates insulin-mediated glucose uptake and is a target of Rho-kinase (Rock); however, the relationship between age-related insulin resistance and Rock signaling specifically in skeletal muscle and adipose tissue is unknown. We evaluated the content and activity of Rock in C2C12 myotubes, and in skeletal muscle and white adipose tissue (WAT) from two rodent models that differ in their patterns of body fat accumulation during aging (Wistar and Fischer 344 rats). Body fat gain in the Wistar rats was greater than in Fischer rats and only Wistar rats had impairment of whole-body insulin sensitivity. Rock activity and insulin signaling were impaired in skeletal muscle in both rat models, but only middle-aged Wistar rats had higher Rock activity in WAT. These data are consistent with a positive role of Rock in regulating insulin signaling in both skeletal muscle and its negative role in the adipose tissue, suggesting that Rock activity in adipose tissue is important in age-related insulin resistance.en
dc.description.affiliationLaboratory of Molecular Biology of Exercise University of Campinas (UNICAMP)
dc.description.affiliationLaboratory of Functional Properties in Foods School of Applied Sciences (FCA) University of Campinas (UNICAMP)
dc.description.affiliationPostgraduate Program in Rehabilitation and Functional Performance Ribeirão Preto Medical School Usp
dc.description.affiliationSchool of Physical Education and Sport of Ribeirão Preto University of São Paulo (USP)
dc.description.affiliationOcrc - Obesity and Comorbidities Research Center University of Campinas (UNICAMP)
dc.description.affiliationPostgraduate Program in Motor Science - São Paulo State University (UNESP)
dc.description.affiliationCepece - Center of Research in Sport Sciences School of Applied Sciences University of Campinas (UNICAMP)
dc.description.affiliationLaboratory of Nutritional Genomics University of Campinas (UNICAMP)
dc.description.affiliationUnespPostgraduate Program in Motor Science - São Paulo State University (UNESP)
dc.format.extent432-436
dc.identifierhttp://dx.doi.org/10.1093/gerona/gly293
dc.identifier.citationJournals of Gerontology - Series A Biological Sciences and Medical Sciences, v. 75, n. 3, p. 432-436, 2020.
dc.identifier.doi10.1093/gerona/gly293
dc.identifier.issn1758-535X
dc.identifier.issn1079-5006
dc.identifier.scopus2-s2.0-85073830240
dc.identifier.urihttp://hdl.handle.net/11449/198040
dc.language.isoeng
dc.relation.ispartofJournals of Gerontology - Series A Biological Sciences and Medical Sciences
dc.sourceScopus
dc.subjectAdipose tissue
dc.subjectAging
dc.subjectInsulin signaling
dc.subjectMuscle
dc.subjectRho-kinase
dc.titleThe effects of aging on rho-kinase and insulin signaling in skeletal muscle and white adipose tissue of ratsen
dc.typeArtigo
dspace.entity.typePublication

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