Dihydroisocoumarins produced by Xylaria sp and Penicillium sp., endophytic fungi associated with Piper aduncum and Alibertia macrophylla
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Elsevier B.V.
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The dihydroisocoumarin (3R, 4R)-3,4-dihydro-4,6-dihydroxy-3-methyl-1-oxo-1H-isochromene-5-carboxylic acid (1) was isolated from Xylaria sp., a fungus associated with Piper aduncum (Piperaceae). Additionally, two known compounds, (R)-7-hydroxymellein (2) and (3R, 4R)-4,7-dihydroxymellein (3), were isolated from Penicillium sp. associated to Alibertia macrophylla (Rubiaceae). The structures of all compounds were elucidated by analysis of spectroscopic data. The dihydrocoumarin derivatives 1-3 showed antifungal and acetylcholinesterase (AChE) inhibitory activities in vitro. (C) 2010 Phytochemical Society of Europe. Published by Elsevier B. V. All rights reserved.
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Dihydroisocoumarins, Endophytic fungi, Bioactive compounds
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Inglês
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Phytochemistry Letters. Amsterdam: Elsevier B.V., v. 4, n. 2, p. 93-96, 2011.
