Publicação: The genome sequence of the plant pathogen Xylella fastidiosa: The Xylella fastidiosa consortium of the organization for nucleotide sequencing and analysis, Sao Paulo, Brazil
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Macmillan Publishers Ltd
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Xylella fastidiosa is a fastidious, xylem-limited bacterium that causes a range of economically important plant diseases. Here we report the complete genome sequence of X. fastidiosa clone 9a5c, which causes citrus variegated chlorosis - a serious disease of orange trees. The genome comprises a 52.7% GC-rich 2,679,305-base-pair (bp) circular chromosome and 'two plasmids of 51,158 bp and 1,285 bp. We can assign putative functions to47% of the 2,904 predicted coding regions. Efficient metabolic functions are predicted, with sugars as the principal energy and carbon source, supporting existence in the nutrient-poor xylem sap. The mechanisms associated with pathogenicity and virulence involve toxins, antibiotics and ion sequestration systems, as well as bacterium-bacterium and bacterium-host interactions mediated by a range of proteins. Orthologues of some of these proteins have only been identified in animal and human pathogens; their presence in X. fastidiosa indicates that the molecular basis for bacterial pathogenicity is both conserved and independent of host. At least 83 genes are bacteriophage-derived and include virulence-associated genes from other bacteria, providing direct evidence of phage-mediated horizontal gene transfer.
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carrier protein, bacterial genetics, bacterial metabolism, bacterium, bacterium adherence, energy metabolism, gene sequence, genetic conservation, genetic transcription, genome, nonhuman, nucleotide sequence, plant, priority journal, review, sequence analysis, Bacterial Adhesion, Bacterial Proteins, Biological Transport, Chromosome Mapping, Citrus, DNA Repair, DNA, Bacterial, Energy Metabolism, Genome, Bacterial, Molecular Sequence Data, Plants, Plants, Toxic, Protein Biosynthesis, Pseudomonadaceae, Sequence Analysis, DNA, Tobacco, Transcription, Genetic, Virulence, Animalia, Bacteria (microorganisms), Citrus sinensis, Fungi, Xylella fastidiosa
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Inglês
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Nature, v. 406, n. 6792, p. 151-157, 2000.
