Candida parapsilosis complex water isolates from a haemodialysis unit: biofilm production and in vitro evaluation of the use of clinical antifungals
dc.contributor.author | Pires, Regina Helena [UNESP] | |
dc.contributor.author | Santos, Jaime Maia dos [UNESP] | |
dc.contributor.author | Zaia, José Eduardo | |
dc.contributor.author | Martins, Carlos Henrique Gomes | |
dc.contributor.author | Mendes-Giannini, Maria José Soares [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de Franca Laboratório de Pesquisa em Microbiologia Aplicada | |
dc.date.accessioned | 2014-05-20T13:16:52Z | |
dc.date.available | 2014-05-20T13:16:52Z | |
dc.date.issued | 2011-09-01 | |
dc.description.abstract | Candida parapsilosis, currently divided into three distinct species, proliferates in glucose-rich solutions and has been associated with infections resulting from the use of medical devices made of plastic, an environment common in dialysis centres. The aims of this study were (i) to screen for Candida orthopsilosis and Candida metapsilosis (100 environmental isolates previously identified as C. parapsilosis), (ii) to test the ability of these isolates to form biofilm and (iii) to investigate the in vitro susceptibility of Candida spp biofilms to the antifungal agents, fluconazole (FLC) and amphotericin B (AMB). Isolates were obtained from a hydraulic circuit collected from a haemodialysis unit. Based on molecular criteria, 47 strains were re-identified as C. orthopsilosis and 53 as C. parapsilosis. Analyses using a formazan salt reduction assay and total viable count, together with microscopy studies, revealed that 72 strains were able to form biofilm that was structurally similar, but with minor differences in morphology. A microtitre-based colorimetric assay used to test the susceptibility of fungal biofilms to AMB and FLC demonstrated that the C. parapsilosis complex displayed an increased resistance to these antifungal agents. The results from these analyses may provide a basis for implementing quality controls and monitoring to ensure the microbiological purity of dialysis water, including the presence of yeast. | en |
dc.description.affiliation | Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Análises Clínicas | |
dc.description.affiliation | Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Fitossanidade Vegetal | |
dc.description.affiliation | Universidade de Franca Laboratório de Pesquisa em Microbiologia Aplicada | |
dc.description.affiliationUnesp | Universidade Estadual Paulista Faculdade de Ciências Farmacêuticas Departamento de Análises Clínicas | |
dc.description.affiliationUnesp | Universidade Estadual Paulista Faculdade de Ciências Agrárias e Veterinárias Departamento de Fitossanidade Vegetal | |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description.sponsorshipId | PADC/FCFAr-UNESP: 2009/54 | |
dc.format.extent | 646-654 | |
dc.identifier | http://www.scielo.br/scielo.php?pid=S0074-02762011000600002&script=sci_arttext | |
dc.identifier.citation | Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 6, p. 646-654, 2011. | |
dc.identifier.file | S0074-02762011000600002.pdf | |
dc.identifier.issn | 0074-0276 | |
dc.identifier.lattes | 6585937888894798 | |
dc.identifier.orcid | 0000-0002-8059-0826 | |
dc.identifier.scielo | S0074-02762011000600002 | |
dc.identifier.uri | http://hdl.handle.net/11449/3553 | |
dc.identifier.wos | WOS:000296022400002 | |
dc.language.iso | eng | |
dc.publisher | Instituto Oswaldo Cruz, Ministério da Saúde | |
dc.relation.ispartof | Memórias do Instituto Oswaldo Cruz | |
dc.relation.ispartofjcr | 2.833 | |
dc.relation.ispartofsjr | 1,172 | |
dc.rights.accessRights | Acesso aberto | pt |
dc.source | SciELO | |
dc.subject | Candida parapsilosis | en |
dc.subject | Candida orthopsilosis | en |
dc.subject | Biofilm | en |
dc.subject | haemodialysis solution | en |
dc.title | Candida parapsilosis complex water isolates from a haemodialysis unit: biofilm production and in vitro evaluation of the use of clinical antifungals | en |
dc.type | Artigo | pt |
dcterms.license | http://www.scielo.br/revistas/mioc/paboutj.htm | |
dcterms.license | http://www.scielo.br/revistas/mioc/paboutj.htm | |
dspace.entity.type | Publication | |
relation.isDepartmentOfPublication | a83d26d6-5383-42e4-bb3c-2678a6ddc144 | |
relation.isDepartmentOfPublication.latestForDiscovery | a83d26d6-5383-42e4-bb3c-2678a6ddc144 | |
relation.isOrgUnitOfPublication | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
relation.isOrgUnitOfPublication.latestForDiscovery | 95697b0b-8977-4af6-88d5-c29c80b5ee92 | |
unesp.author.lattes | 6585937888894798 | |
unesp.author.orcid | 0000-0002-8059-0826[5] | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabal | pt |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquara | pt |
unesp.department | Fitossanidade - FCAV | pt |
unesp.department | Análises Clínicas - FCF | pt |
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