Effect of zoledronic acid used in the root surface treatment of late replanted teeth: A study in rats

This study evaluated the use of zoledronic acid, a resorption inhibitor, as a medication for root resorption treatment of late replanted teeth. Twenty-four maxillary right central incisors of rats were avulsed and kept dry for 30 min. Then, the teeth were divided into 2 groups. In group I, root surface was treated with 2% sodium fluoride for 20 min; in group II, 10-6M zoledronic acid solution was used for 20 min. All root canals were filled with calcium hydroxide. Next, teeth were replanted in their respective sockets. After 15 and 60 days post-replantation, the animals were killed and the anatomic pieces were obtained and prepared for microscopic and morphometric analyses. The results showed that zoledronic acid was capable of limiting the occurrence of root resorption and preserving cementum resorption. Further research must be performed to confirm the use of zoledronic acid in root surface treatment of late replanted teeth.

Keywords

Root resorption, Tooth replantation, Zoledronic acid, bisphosphonic acid derivative, bone density conservation agent, calcium hydroxide, fluoride sodium, imidazole derivative, root canal filling material, zoledronic acid, animal, cementum, connective tissue, drug effect, endodontics, image processing, male, methodology, rat, time, tooth disease, tooth injury, tooth root, tooth socket, Wistar rat, Animals, Bone Density Conservation Agents, Calcium Hydroxide, Connective Tissue, Dental Cementum, Diphosphonates, Image Processing, Computer-Assisted, Imidazoles, Male, Rats, Rats, Wistar, Root Canal Filling Materials, Root Canal Obturation, Root Canal Preparation, Root Resorption, Sodium Fluoride, Time Factors, Tooth Ankylosis, Tooth Avulsion, Tooth Replantation, Tooth Root, Tooth Socket