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Transplacental transmission of Toxoplasma gondii in reinfected pregnant female canines

dc.contributor.authorBresciani, Katia Denise Saraiva [UNESP]
dc.contributor.authorCosta, A. J. [UNESP]
dc.contributor.authorToniollo, Gilson Hélio [UNESP]
dc.contributor.authorLuvizzoto, M. C. R. [UNESP]
dc.contributor.authorKanamura, C. T.
dc.contributor.authorMoraes, Flávio Ruas de [UNESP]
dc.contributor.authorPerri, S. H. V. [UNESP]
dc.contributor.authorGennari, S. M.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionInstituto Adolfo Lutz (IAL)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2014-05-20T13:15:22Z
dc.date.available2014-05-20T13:15:22Z
dc.date.issued2009-04-01
dc.description.abstractTwelve pregnant female canines, naturally infected with Toxoplasma gondii, were reinfected with T. gondii: three (GI) received tachyzoites subcutaneously (1.0 x 107), three (GII) were orally inoculated with oocysts (1.5 x 104), and six (GIII) were kept as a nonreinfected control group. All the reinfected female canines (GI and GII) miscarried or presented fetal death, while only one GIII female presented a stillborn in a litter of four pups (P < 0.01). Fever, lymphoadenopathy, miscarriage, and fetal death were the main clinical alterations observed. The highest serological titers detected through the indirect fluorescence antibody test (IFAT) were 1,024 (GI) and 4,096 (GII). In group III, the titers ranged between 64 and 256. By bioassays in mice, T. gondii was isolated in 17 organs of the reinfected adult canines, in 11 of the control group, and in 20 of the neonates. Positive immunostaining of cysts and/or tachyzoites were observed in 26 canine tissues (14 from GI and GII and ten from GIII). The agent was detected by immunohistochemistry in the encephalon of a neonate and in the spinal cord of a stillborn, thus, confirming that T. gondii infected canine fetuses, provoking miscarriages, even in bitches that presented primoinfection.en
dc.description.affiliationUNESP Univ Estadual Paulista, Fac Odontol, BR-16050680 São Paulo, Brazil
dc.description.affiliationUNESP, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil
dc.description.affiliationInst Adolfo Lutz Registro, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med Vet & Zootecnia, São Paulo, Brazil
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Fac Odontol, BR-16050680 São Paulo, Brazil
dc.description.affiliationUnespUNESP, Fac Ciencias Agr & Vet, Jaboticabal, SP, Brazil
dc.format.extent1213-1217
dc.identifierhttp://dx.doi.org/10.1007/s00436-008-1317-5
dc.identifier.citationParasitology Research. New York: Springer, v. 104, n. 5, p. 1213-1217, 2009.
dc.identifier.doi10.1007/s00436-008-1317-5
dc.identifier.issn0932-0113
dc.identifier.lattes5604409973209376
dc.identifier.lattes5950594366829647
dc.identifier.urihttp://hdl.handle.net/11449/2539
dc.identifier.wosWOS:000264495900033
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofParasitology Research
dc.relation.ispartofjcr2.558
dc.relation.ispartofsjr0,991
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.titleTransplacental transmission of Toxoplasma gondii in reinfected pregnant female caninesen
dc.typeArtigo
dcterms.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dcterms.rightsHolderSpringer
dspace.entity.typePublication
unesp.author.lattes5604409973209376
unesp.author.lattes5950594366829647
unesp.author.orcid0000-0002-8767-8855[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Agrárias e Veterinárias, Jaboticabalpt
unesp.departmentMedicina Veterinária Preventiva e Reprodução Animal - FCAVpt
unesp.departmentPatologia Veterinária - FCAVpt

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