Reinforcing properties of fencamfamine: Involvement of dopamine and opioid receptors
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Elsevier
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Fencamfamine (FCF) is a psychostimulant classified as an indirect dopamine agonist. The conditioning place preference (CPP) paradigm was used to investigate the reinforcing properties of FCF. After initial preferences had been determined, animals were conditioned with FCF (1.75, 3.5, or 7.0 mg/kg; IP). Only at the dose of 3.5 mg/kg FCF produced a significant place preference. Pretreatment with SCH23390 (0.05 mg/kg, SC) or naloxone (1.0 mg/kg SC) 10 min before FCF (3.5 mg/kg; IP) blocked both FCF-induced hyperactivity and CPP. Pretreatment with metoclopramide (10.0 mg/kg; IP) or pimozide (1.0 mg/kg, IP), respectively, 30 min or 4 h before FCF (3.5 mg/kg; IP), which blocked the FCF-induced locomotor activity, failed to influence place conditioning produced by FCF. In conclusion, the present study suggests that dopamine D 1 and opioid receptors are related to FCF reinforcing effect, while dopamine D 2 subtype receptor was ineffective in modifying FCF-induced CPP.
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Dopamine receptors Fencamfamine Opioid receptors Place conditioning Reinforcement 8 chloro 2,3,4,5 tetrahydro 3 methyl 5 phenyl 1h 3 benzazepin 7 ol hydrogen maleate dopamine 1 receptor dopamine 2 receptor dopamine receptor dopamine receptor stimulating agent fencamfamin metoclopramide naloxone opiate receptor pimozide psychostimulant agent receptor subtype animal experiment conditioning controlled study drug antagonism hyperactivity intraperitoneal drug administration nonhuman place preference priority journal rat reinforcement subcutaneous drug administration Animal Binding, Competitive Central Nervous System Stimulants Conditioning, Operant Metoclopramide Naloxone Norbornanes Pimozide Rats Receptors, Dopamine D1 Receptors, Dopamine D2 Receptors, Opioid, mu Reinforcement (Psychology) Sch-23390 Animalia
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Inglês
Citação
Pharmacology Biochemistry and Behavior, v. 50, n. 1, p. 35-40, 1995.
