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An immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogs

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dc.contributor.authorPalmieri, Chiara
dc.contributor.authorHood, Grace
dc.contributor.authorFonseca-Alves, Carlos Eduardo [UNESP]
dc.contributor.authorLaufer-Amorim, Renée [UNESP]
dc.contributor.authorAllavena, Rachel
dc.contributor.institutionThe University of Queensland
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T16:08:07Z
dc.date.available2019-10-06T16:08:07Z
dc.date.issued2019-02-01
dc.description.abstractThe aim of this study was to characterise T and B lymphocyte density in 6 normal prostates, 15 benign prostatic hyperplasia (BPH) and 24 prostate carcinomas (PCs) in dogs by immunohistochemistry. Results revealed a statistically significant increase of T and B cells in PC compared to normal specimens and BPH. Regarding PC histological variants, lower number of CD3 + and CD79 + lymphocytes were observed in the most undifferentiated (solid) type. CD3 + cell density was positively correlated with survival time. These results may help in understanding the immunological mechanisms regulating BPH and PC development and progression, as well as providing background data for future immunotherapeutic trials.en
dc.description.affiliationSchool of Veterinary Science The University of Queensland, Gatton Campus
dc.description.affiliationDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science Univ. Estadual Paulista – UNESP
dc.description.affiliationUnespDepartment of Veterinary Clinic School of Veterinary Medicine and Animal Science Univ. Estadual Paulista – UNESP
dc.format.extent189-192
dc.identifierhttp://dx.doi.org/10.1016/j.rvsc.2018.11.022
dc.identifier.citationResearch in Veterinary Science, v. 122, p. 189-192.
dc.identifier.doi10.1016/j.rvsc.2018.11.022
dc.identifier.issn1532-2661
dc.identifier.issn0034-5288
dc.identifier.scopus2-s2.0-85057628500
dc.identifier.urihttp://hdl.handle.net/11449/188440
dc.language.isoeng
dc.relation.ispartofResearch in Veterinary Science
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectCD3
dc.subjectCD79
dc.subjectDogs
dc.subjectImmunohistochemistry
dc.subjectLymphocytes
dc.subjectProstate cancer
dc.titleAn immunohistochemical study of T and B lymphocyte density in prostatic hyperplasia and prostate carcinoma in dogsen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.orcid0000-0002-6702-6139[3]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina Veterinária e Zootecnia, Botucatupt
unesp.departmentClínica Veterinária - FMVZpt

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Botucatu - FMVZ - Faculdade de Medicina Veterinária e Zootecnia