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Role of central α1- and α2-adrenoceptors on the dipsogenic and cardiovascular effect of angiotensin II

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dc.contributor.authorColombari, Eduardo [UNESP]
dc.contributor.authorSaad, Wilson Abrão [UNESP]
dc.contributor.authorDe Arruda Camargo, Luiz Antonio [UNESP]
dc.contributor.authorRenzi, Antonio [UNESP]
dc.contributor.authorLuca Junior, Laurival Antonio de [UNESP]
dc.contributor.authorMenani, José Vanderlei [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T09:09:39Z
dc.date.available2014-05-27T09:09:39Z
dc.date.issued1990-08-01
dc.description.abstractWe investigated the effects of previous central treatment with prazosin (an α1-adrenoceptor antagonist) or clonidine (an α2-adrenoceptor agonist) on the dipsogenic, pressor and tachycardic responses produced by intracerebroventricular (ICV) injection of angiotensin II (AII) in conscious rats. Holtzman rats with a chronic cannula implanted in the lateral ventricle were tested for dipsogenic and cardiovascular (arterial pressure and heart rate) responses in separate experiments. Previous ICV treatment with clonidine (20, 40, 80 and 120 nmol) abolished the pressor, tachycardic and dipsogenic effects of ICV AII. After all doses of prazosin (40, 80 and 120 nmol), AII induced bradycardic responses, but only the 80 and 120 nmol doses of prazosin reduced the pressor responses to AII. Prazosin produced no alteration in the dipsogenic effect of AII. The results show that the periventricular α1-adrenoceptors are involved only in the cardiovascular responses produced by central AII, whereas clonidine acting through α2-adrenergic and/or imidazole receptors can modulate all actions of AII. © 1990.en
dc.description.affiliationDepartment of Physiology School of Dentistry Paulista State University, Araraquara, SP 14800
dc.description.affiliationUnespDepartment of Physiology School of Dentistry Paulista State University, Araraquara, SP 14800
dc.format.extent893-896
dc.identifierhttp://dx.doi.org/10.1016/0091-3057(90)90096-Z
dc.identifier.citationPharmacology, Biochemistry and Behavior, v. 36, n. 4, p. 893-896, 1990.
dc.identifier.doi10.1016/0091-3057(90)90096-Z
dc.identifier.issn0091-3057
dc.identifier.lattes4544450092427426
dc.identifier.lattes6551236936295697
dc.identifier.lattes1023597870118105
dc.identifier.lattes339253755971890
dc.identifier.scopus2-s2.0-0025108941
dc.identifier.urihttp://hdl.handle.net/11449/130582
dc.identifier.wosWOS:A1990DT68700033
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPharmacology Biochemistry and Behavior
dc.relation.ispartofjcr2.538
dc.relation.ispartofsjr1,150
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectα-Adrenoceptors
dc.subjectAngiotensin II
dc.subjectArterial pressure
dc.subjectThirst
dc.subjectAlpha 1 adrenergic receptor
dc.subjectAlpha 2 adrenergic receptor
dc.subjectAngiotensin
dc.subjectClonidine
dc.subjectPrazosin
dc.subjectAnimal experiment
dc.subjectBlood pressure
dc.subjectHeart rate
dc.subjectIntracerebroventricular drug administration
dc.subjectMale
dc.subjectNonhuman
dc.subjectPriority journal
dc.subjectRat
dc.subjectThirst
dc.subjectAnimal
dc.subjectBlood Pressure
dc.subjectBrain
dc.subjectCentral Nervous System
dc.subjectClonidine
dc.subjectDrinking Behavior
dc.subjectHeart Rate
dc.subjectHemodynamics
dc.subjectInjections, Intraventricular
dc.subjectMale
dc.subjectPrazosin
dc.subjectRats
dc.subjectReceptors, Adrenergic, alpha
dc.subjectStereotaxic Techniques
dc.subjectSupport, Non-U.S. Gov't
dc.subjectAnimalia
dc.titleRole of central α1- and α2-adrenoceptors on the dipsogenic and cardiovascular effect of angiotensin IIen
dc.typeArtigo
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
unesp.author.lattes4544450092427426[1]
unesp.author.lattes6551236936295697
unesp.author.lattes1023597870118105
unesp.author.lattes339253755971890
unesp.author.orcid0000-0001-8270-2652[5]
unesp.author.orcid0000-0002-1395-4036[1]
unesp.author.orcid0000-0003-1167-4441[6]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Odontologia, Araraquarapt
unesp.departmentFisiologia e Patologia - FOARpt

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Araraquara - FOAR - Faculdade de Odontologia