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Sperm quality and fertility in rats after prenatal exposure to low doses of TCDD: A three-generation study

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dc.contributor.authorSanabria, Marciana [UNESP]
dc.contributor.authorCucielo, Maira Smaniotto [UNESP]
dc.contributor.authorGuerra, Marina Trevizan [UNESP]
dc.contributor.authordos Santos Borges, Cibele [UNESP]
dc.contributor.authorBanzato, Thais Petrochelli [UNESP]
dc.contributor.authorPerobelli, Juliana Elaine [UNESP]
dc.contributor.authorLeite, Gabriel Adan Araújo [UNESP]
dc.contributor.authorAnselmo-Franci, Janete Aparecida
dc.contributor.authorDe Grava Kempinas, Wilma [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:04:04Z
dc.date.available2018-12-11T17:04:04Z
dc.date.issued2016-10-01
dc.description.abstractExposure to Tetrachlorodibenzo-p-dioxin (TCDD) in male rats promotes, decreased sperm concentration, alterations in motility and in sperm transit time. We evaluated the effect transgenerational of in utero exposure to low doses TCDD in the sperm quality. Pregnant rats (F0) were exposed to 0.1; 0.5 and 1.0 μg of TCDD, on gestational day 15, coincides with the end of most organogenesis in the fetus. Adult male offspring (F1, F2 and F3 generation) were investigated for fertility after artificial insemination in utero. After collection of the uterus and ovaries, the numbers of corpora lutea and implants were determined. TCDD provoked alterations in sperm morphology and diminution in serum testosterone levels and sperm transit time in the cauda epididymis. The fertility significantly decreased in all the generations, at least at one dose. In conclusion, TCDD exposure decreases rat sperm quality and fertility in adult male offspring and this effects persist into the next generation.en
dc.description.affiliationLaboratory of Reproductive and Developmental Biology and Toxicology Department of Morphology Institute of Biosciences of Botucatu UNESP—Univ Estadual, Botucatu
dc.description.affiliationDepartment of Morphology Stomatology and Physiology School of Dentistry USP—University of São Paulo, Ribeirão Preto
dc.description.affiliationUnespLaboratory of Reproductive and Developmental Biology and Toxicology Department of Morphology Institute of Biosciences of Botucatu UNESP—Univ Estadual, Botucatu
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2012/00365-6
dc.format.extent29-38
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2016.06.019
dc.identifier.citationReproductive Toxicology, v. 65, p. 29-38.
dc.identifier.doi10.1016/j.reprotox.2016.06.019
dc.identifier.file2-s2.0-84977614031.pdf
dc.identifier.issn1873-1708
dc.identifier.issn0890-6238
dc.identifier.scopus2-s2.0-84977614031
dc.identifier.urihttp://hdl.handle.net/11449/173192
dc.language.isoeng
dc.relation.ispartofReproductive Toxicology
dc.relation.ispartofsjr0,846
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectDioxin
dc.subjectEpididymis
dc.subjectFertility
dc.subjectSperm quality
dc.subjectTransgenerational effect
dc.titleSperm quality and fertility in rats after prenatal exposure to low doses of TCDD: A three-generation studyen
dc.typeArtigo
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentMorfologia - IBBpt

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