Atenolol reduces salivary activity in pups of spontaneously hypertensive and normotensive rats treated during pregnancy and lactation

The salivary activity in pups of spontaneously hypertensive rats (SHR) and Wistar (W) rats treated with atenolol during pregnancy, and lactation was evaluated. Atenolol's anti-hypertensive effect on the SHR rats was noticed from the beginning of treatment. Atenolol-treated SHR and Wistar rat pups showed a decrease in salivary gland weight, salivary flow, and protein concentration, with no alteration in salivary amylase activity. Atenolol's effect on salivary glands can interfere with oral health maintenance. Copyright © Informa Healthcare USA, Inc.

Keywords

Atenolol, Salivary glands, Spontaneously hypertensive rats (SHR), amylase, atenolol, animal experiment, animal model, antihypertensive activity, controlled study, enzyme activity, female, health, hypertension, lactation, male, nonhuman, pregnancy, rat, salivary gland, salivation, Adrenergic beta-Antagonists, Amylases, Animals, Female, Hypertension, Lactation, Male, Organ Size, Osmolar Concentration, Pregnancy, Pregnancy Complications, Cardiovascular, Rats, Rats, Inbred SHR, Rats, Wistar, Saliva, Salivary Glands, Salivary Proteins