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Publicação:
Impact of maternal and postnatal zinc dietary status on the prostate of pubescent and adult rats

dc.contributor.authorCamora, Lucas F. [UNESP]
dc.contributor.authorSilva, Ana Priscila G.
dc.contributor.authorSantos, Sérgio A.A. [UNESP]
dc.contributor.authorJustulin, Luis A. [UNESP]
dc.contributor.authorPerobelli, Juliana E.
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.authorScarano, Wellerson R. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.date.accessioned2018-12-11T17:31:47Z
dc.date.available2018-12-11T17:31:47Z
dc.date.issued2017-11-01
dc.description.abstractZinc is important for cell physiology and alteration of its levels during development can modulate a series of biological events. The aim of this study was to investigate whether dietary zinc deficiency or supplementation during morphogenesis and early postnatal development could interfere in prostate maturation. Pregnant rats were exposed to a standard diet (NZ:35 mg Zn/kg chow), low-zinc diet (LZ:3 mg of Zn/kg chow) and zinc-supplemented diet (HZ:180 mg/Kg chow) from gestational day 10 (GD10) through postnatal day 21 (PND21). After weaning, male offspring were divided into three groups that were submitted to the same food conditions as their mothers until PND53. The animals were euthanized at PND53 and PND115. The ventral prostate was removed, weighed and its fragments were subjected to histological, western blot and zymography analysis. PND53: body and prostate weight were lower in LZ compared to NZ; the epithelial compartment was reduced while the stromal compartment was increased in LZ compared to NZ; there was an increase in the amount of collagen and reduction in AR and SIRT1 expression in LZ compared to NZ. PND115: body weight was lower in LZ compared to NZ and prostate weight was similar among the groups; peripheral physiological hyperplasia was observed, as well as an increased epithelial proliferation index and reduced PAR4 expression in LZ and HZ compared to NZ. Zinc deficiency during prostate morphogenesis and differentiation is potentially harmful to its morphology, however, by restoring the standard dietary environment, the gland responds to the new microenvironment independent of the previous dietary condition.en
dc.description.affiliationDepartment of Morphology Institute of Biosciences São Paulo State University (Unesp)
dc.description.affiliationDepartment of Sciences of the Sea Federal University of São Paulo UNIFESP
dc.description.affiliationUnespDepartment of Morphology Institute of Biosciences São Paulo State University (Unesp)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 2014/25932-6
dc.format.extent1203-1213
dc.identifierhttp://dx.doi.org/10.1002/cbin.10756
dc.identifier.citationCell Biology International, v. 41, n. 11, p. 1203-1213, 2017.
dc.identifier.doi10.1002/cbin.10756
dc.identifier.issn1095-8355
dc.identifier.issn1065-6995
dc.identifier.lattes3278528112652257
dc.identifier.scopus2-s2.0-85015229256
dc.identifier.urihttp://hdl.handle.net/11449/178714
dc.language.isoeng
dc.relation.ispartofCell Biology International
dc.relation.ispartofsjr0,712
dc.relation.ispartofsjr0,712
dc.rights.accessRightsAcesso restrito
dc.sourceScopus
dc.subjectfetal programming
dc.subjectpre puberty treatment
dc.subjectprostate development
dc.subjectpuberty
dc.subjectstromal remodeling
dc.subjectzinc deficiency
dc.titleImpact of maternal and postnatal zinc dietary status on the prostate of pubescent and adult ratsen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes3278528112652257
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Biociências, Botucatupt
unesp.departmentMorfologia - IBBpt

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