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Cellular Griffiths-like phase

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dc.contributor.authorSquillante, Lucas [UNESP]
dc.contributor.authorMello, Isys F. [UNESP]
dc.contributor.authorRicco, Luciano S.
dc.contributor.authorMinicucci, Marcos F. [UNESP]
dc.contributor.authorUkpong, Aniekan Magnus
dc.contributor.authorSeridonio, Antonio C. [UNESP]
dc.contributor.authorLagos-Monaco, Roberto E. [UNESP]
dc.contributor.authorde Souza, Mariano [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionUniversity of Iceland
dc.contributor.institutionUniversity of KwaZulu-Natal
dc.contributor.institutionNational Institute for Theoretical and Computational Sciences (NITheCS)
dc.date.accessioned2025-04-29T19:30:42Z
dc.date.issued2024-08-15
dc.description.abstractProtein compartmentalization in the frame of a liquid-liquid phase separation is a key mechanism to optimize spatiotemporal control of biological systems. Such a compartmentalization process reduces the intrinsic noise in protein concentration due to stochasticity in gene expression. Employing Flory-Huggins solution theory, Avramov/Casalini's model, and the Grüneisen parameter, we unprecedentedly propose a cellular Griffiths-like phase (CGLP), which can impact its functionality and self-organization. The here-proposed CGLP is key ranging from the understanding of primary organisms' evolution to the treatment of diseases. Our findings pave the way for an alternative Biophysics approach to investigate coacervation processes.en
dc.description.affiliationSão Paulo State University (Unesp) IGCE - Physics Department, SP
dc.description.affiliationScience Institute University of Iceland, Dunhagi-3
dc.description.affiliationDepartment of Internal Medicine Botucatu Medical School UNESP – Univ Estadual Paulista
dc.description.affiliationTheoretical and Computational Condensed Matter and Materials Physics Group School of Chemistry and Physics University of KwaZulu-Natal
dc.description.affiliationNational Institute for Theoretical and Computational Sciences (NITheCS)
dc.description.affiliationSão Paulo State University (Unesp) Department of Physics and Chemistry, SP
dc.description.affiliationUnespSão Paulo State University (Unesp) IGCE - Physics Department, SP
dc.description.affiliationUnespDepartment of Internal Medicine Botucatu Medical School UNESP – Univ Estadual Paulista
dc.description.affiliationUnespSão Paulo State University (Unesp) Department of Physics and Chemistry, SP
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipRannís
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdCAPES: 001
dc.description.sponsorshipIdCNPq: 08695/2021-6
dc.description.sponsorshipIdRannís: 163082-051
dc.description.sponsorshipIdFAPESP: 2011/22050-4
dc.description.sponsorshipIdFAPESP: 2017/07845-7
dc.description.sponsorshipIdFAPESP: 2019/24696-0
dc.description.sponsorshipIdCNPq: 303772/2023-9
dc.identifierhttp://dx.doi.org/10.1016/j.heliyon.2024.e34622
dc.identifier.citationHeliyon, v. 10, n. 15, 2024.
dc.identifier.doi10.1016/j.heliyon.2024.e34622
dc.identifier.issn2405-8440
dc.identifier.scopus2-s2.0-85199253127
dc.identifier.urihttps://hdl.handle.net/11449/303785
dc.language.isoeng
dc.relation.ispartofHeliyon
dc.sourceScopus
dc.subjectCell criticality
dc.subjectFlory-Huggins solution theory
dc.subjectGriffiths phase
dc.subjectGrüneisen parameter
dc.subjectPrimary organisms
dc.subjectProtein compartmentalization
dc.titleCellular Griffiths-like phaseen
dc.typeArtigopt
dspace.entity.typePublication
relation.isOrgUnitOfPublicationa3cdb24b-db92-40d9-b3af-2eacecf9f2ba
relation.isOrgUnitOfPublication.latestForDiscoverya3cdb24b-db92-40d9-b3af-2eacecf9f2ba
unesp.author.orcid0000-0003-3433-1353[1]
unesp.author.orcid0000-0002-2466-3402[8]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Geociências e Ciências Exatas, Rio Claropt

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Botucatu - FMB - Faculdade de Medicina
Rio Claro - IGCE - Instituto de Geociências e Ciências Exatas