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Exercise preconditioning modulates genotoxicity induced by doxorubicin in multiple organs of rats

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dc.contributor.authorMartins, Renato Almeida
dc.contributor.authorMinari, Andre Luis
dc.contributor.authorChaves, Marcelo Donizetti
dc.contributor.authorThomatieli dos Santos, Ronaldo Wagner
dc.contributor.authorBarbisan, Luis Fernando [UNESP]
dc.contributor.authorRibeiro, Daniel Araki
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T13:52:13Z
dc.date.available2014-05-20T13:52:13Z
dc.date.issued2012-06-01
dc.description.abstractThe aim of this study was to investigate the effects of exercise in multiple organs of rats treated with doxorubicin. Male adult Wistar rats were distributed into the following groups: sedentary + NaCl; exercise + NaCl; sedentary + doxorubicin; and exercise + doxorubicin. Animals were sacrificed 2?days following injections. Central fragments from heart, liver, and kidney were collected and minced in 0.9% NaCl being cellular suspensions used for the single-cell gel (comet) assay. The results showed that exercise was able to prevent genotoxicity induced by doxorubicin in heart cells. By contrast, exercise was not able to prevent genotoxicity induced by doxorubicin in liver cells. The same occurred to kidney cells, i.e. no statistically significant differences (p?>?0.05) were found when compared with groups not exposed to doxorubicin. Taken together, our results support the idea that exercise could contribute to the protective effect against genotoxicity induced by doxorubicin in heart cells. Copyright (c) 2012 John Wiley & Sons, Ltd.en
dc.description.affiliationUniv Fed São Paulo UNIFESP, Dept Biociencias, BR-11060001 Santos, SP, Brazil
dc.description.affiliationPaulista State Univ UNESP, Dept Morphol, Botucatu, SP, Brazil
dc.description.affiliationUnespPaulista State Univ UNESP, Dept Morphol, Botucatu, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIdCNPq: 561357/2008-0
dc.format.extent293-296
dc.identifierhttp://dx.doi.org/10.1002/cbf.2799
dc.identifier.citationCell Biochemistry and Function. Hoboken: Wiley-blackwell, v. 30, n. 4, p. 293-296, 2012.
dc.identifier.doi10.1002/cbf.2799
dc.identifier.issn0263-6484
dc.identifier.lattes3278528112652257
dc.identifier.urihttp://hdl.handle.net/11449/18656
dc.identifier.wosWOS:000304863800006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofCell Biochemistry and Function
dc.relation.ispartofjcr2.186
dc.relation.ispartofsjr0,520
dc.rights.accessRightsAcesso restrito
dc.sourceWeb of Science
dc.subjectexerciseen
dc.subjectsingle-cell gel (comet) assayen
dc.subjectdoxorubicinen
dc.subjectDNA damageen
dc.subjectratsen
dc.titleExercise preconditioning modulates genotoxicity induced by doxorubicin in multiple organs of ratsen
dc.typeArtigo
dcterms.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dcterms.rightsHolderWiley-blackwell
dspace.entity.typePublication
unesp.author.lattes3278528112652257
unesp.author.orcid0000-0003-2135-0678[3]
unesp.author.orcid0000-0001-7010-2799[4]
unesp.campusUniversidade Estadual Paulista (Unesp), Instituto de Biociências, Botucatupt
unesp.departmentMorfologia - IBBpt

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Botucatu - IBB - Instituto de Biociências