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Induction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-rays

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dc.contributor.authorStoll, L. B.
dc.contributor.authorCremonesi, F. C. A.
dc.contributor.authorPires, L. T. A.
dc.contributor.authorZucchi, T. D.
dc.contributor.authorZucchi, T. M. A. D.
dc.contributor.institutionUniversidade de Franca (UNIFRAN)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionCentro Universitário Moura Lacerda
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-27T11:23:37Z
dc.date.available2014-05-27T11:23:37Z
dc.date.issued2008-07-30
dc.description.abstractAs a contribution towards detecting the genetic effects of low doses of genotoxic physical agents, this paper deals with the consequences of low-dose X-rays in the Aspergillus nidulans genome. The irradiation doses studied were those commonly used in dental clinics (1-5 cGy). Even very low doses promoted increased mitotic crossing-over frequencies in diploid strains heterozygous for several genetic markers including the ones involved in DNA repair and recombination mechanisms. Genetic markers of several heterozygous strains were individually analyzed disclosing that some markers were especially sensitive to the treatments. These markers should be chosen as bio-indicators in the homozygotization index assay to better detect the recombinogenic/ carcinogenic genomic effects of low-dose X-rays. ©FUNPEC-RP.en
dc.description.affiliationFaculdade de Odontologia Universidade de Franca, Franca, SP
dc.description.affiliationFaculdade de Odontologia Universidade de São Paulo, Ribeirão Preto, SP
dc.description.affiliationCentro Universitário Moura Lacerda, Ribeirão Preto, SP
dc.description.affiliationDepartamento de Parasitologia Instituto de Ciências Biomédicas Universidade de São Paulo, São Paulo, SP
dc.description.affiliationDepartamento de Ciências Biológicas and Biotecnologia Universidade do Estado de São Paulo, Assis, SP
dc.format.extent467-475
dc.identifierhttp://dx.doi.org/10.4238/vol7-2gmr414
dc.identifier.citationGenetics and Molecular Research, v. 7, n. 2, p. 467-475, 2008.
dc.identifier.doi10.4238/vol7-2gmr414
dc.identifier.file2-s2.0-47949095090.pdf
dc.identifier.issn1676-5680
dc.identifier.scopus2-s2.0-47949095090
dc.identifier.urihttp://hdl.handle.net/11449/70498
dc.language.isoeng
dc.relation.ispartofGenetics and Molecular Research
dc.relation.ispartofsjr0,439
dc.rights.accessRightsAcesso aberto
dc.sourceScopus
dc.subjectAspergillus nidulans
dc.subjectDNA damage
dc.subjectGenotoxicity tests
dc.subjectHomozygotization index assay
dc.subjectLow-dose X-rays
dc.subjectMitotic crossing-over
dc.subjectcontrolled study
dc.subjectcrossing over
dc.subjectdiploidy
dc.subjectDNA recombination
dc.subjectDNA repair
dc.subjectfungal gene
dc.subjectfungal strain
dc.subjectgenotoxicity
dc.subjectlow energy radiation
dc.subjectmitosis
dc.subjectnonhuman
dc.subjectradiation mutagenesis
dc.subjectX irradiation
dc.subjectCrossing Over, Genetic
dc.subjectDiploidy
dc.subjectDNA Damage
dc.subjectDose-Response Relationship, Radiation
dc.subjectHomozygote
dc.subjectMitosis
dc.subjectMutagenicity Tests
dc.subjectX-Rays
dc.subjectEmericella nidulans
dc.titleInduction of mitotic crossing-over in diploid strains of Aspergillus nidulans using low-dose X-raysen
dc.typeArtigo
dcterms.licensehttp://www.geneticsmr.com/node/5
dspace.entity.typePublication

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