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Isolamento e avaliação da atividade biológica dos alcalóides majoritários de Tabernaemontana angulata Mart. ex Müll. Arg., Apocynaceae

dc.contributor.authorde Assis, Camila M. [UNESP]
dc.contributor.authorMoreno, Paulo R. H.
dc.contributor.authorMarx Young, Maria Claudia
dc.contributor.authorde Arruda Campos, Ivan P. [UNESP]
dc.contributor.authorSuffredini, Ivana B. [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionSecretaria Meio Ambiente Estado São Paulo R Migue
dc.date.accessioned2014-05-20T15:31:49Z
dc.date.available2014-05-20T15:31:49Z
dc.date.issued2009-04-01
dc.description.abstract"Isolation and evaluation of the biological activity related to the major alkaloids in Tabernaemontana angulata Mart. ex Mull Arg., Apocynaceae." Introducing-new chemotherapeutic agents is a, great demand. in the control of infections diseases.' Brazil is one of the richest countries in biodiversity and the Laboratorio de Extracao at UNIP has been collecting plants from. the Amazon and Atlantic Rain Forests with the aim of screening for new antibacterial and antitumor plant extracts. Previous studies demonstrated that the ethanol fraction obtained from the crude extract of Tabernaemontana angulata stems showed antibacterial activity against Staphylococcus aureus (ATCC 6538 in the microdilution broth assay. Two alkaloids were the major compounds in the active fraction, verified by thin layer chromatography analysis. In the present study, the total alkaloids were obtained from the crude extract and were fractionated by preparative thin layer chromatography for the isolation of the main components. The isolated. compounds were identified by GC/MS and (1)H-NMR as coronaridine,e and voacangine. The alkaloid fractions obtained from the isolation procedure were tested for antibacterial activity, but no activity was detected.en
dc.description.affiliationUniv Estadual Paulista, Lab Extracao, BR-01310100 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Quim, BR-05513970 São Paulo, Brazil
dc.description.affiliationSecretaria Meio Ambiente Estado São Paulo R Migue, Inst Bot, BR-04301902 São Paulo, Brazil
dc.description.affiliationUniv Estadual Paulista, Programa Posgrad Engn Prod, Inst Ciencias Exatas & Tecnol, BR-04026002 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Lab Extracao, BR-01310100 São Paulo, Brazil
dc.description.affiliationUnespUniv Estadual Paulista, Programa Posgrad Engn Prod, Inst Ciencias Exatas & Tecnol, BR-04026002 São Paulo, Brazil
dc.format.extent626-631
dc.identifierhttp://dx.doi.org/10.1590/S0102-695X2009000400021
dc.identifier.citationRevista Brasileira de Farmacognosia-brazilian Journal of Pharmacognosy. Amsterdam: John Benjamins Publishing Company, v. 19, n. 2B, p. 626-631, 2009.
dc.identifier.fileS0102-695X2009000400021.pdf
dc.identifier.issn0102-695X
dc.identifier.scieloS0102-695X2009000400021
dc.identifier.urihttp://hdl.handle.net/11449/40855
dc.identifier.wosWOS:000271903600022
dc.language.isopor
dc.publisherJohn Benjamins Publishing Company
dc.relation.ispartofRevista Brasileira de Farmacognosia-brazilian Journal of Pharmacognosy
dc.relation.ispartofjcr1.596
dc.rights.accessRightsAcesso aberto
dc.sourceWeb of Science
dc.subjectTabernaemontana angulataen
dc.subjectApocynaceaeen
dc.subjectalkaloidsen
dc.subjectantibacterial activityen
dc.subjectcytotoxicityen
dc.titleIsolamento e avaliação da atividade biológica dos alcalóides majoritários de Tabernaemontana angulata Mart. ex Müll. Arg., Apocynaceaept
dc.title.alternativeIsolation and evaluation of the biological activity related to the major alkaloids in Tabernaemontana angulata Mart. ex Mull. Arg., Apocynaceaeen
dc.typeArtigo
dcterms.rightsHolderJohn Benjamins Publishing Company
dspace.entity.typePublication
unesp.author.orcid0000-0001-5812-6667[2]
unesp.author.orcid0000-0002-2860-6659[3]
unesp.author.orcid0000-0002-5237-101X[5]

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