Isolamento e avaliação da atividade biológica dos alcalóides majoritários de Tabernaemontana angulata Mart. ex Müll. Arg., Apocynaceae
dc.contributor.author | de Assis, Camila M. [UNESP] | |
dc.contributor.author | Moreno, Paulo R. H. | |
dc.contributor.author | Marx Young, Maria Claudia | |
dc.contributor.author | de Arruda Campos, Ivan P. [UNESP] | |
dc.contributor.author | Suffredini, Ivana B. [UNESP] | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Universidade de São Paulo (USP) | |
dc.contributor.institution | Secretaria Meio Ambiente Estado São Paulo R Migue | |
dc.date.accessioned | 2014-05-20T15:31:49Z | |
dc.date.available | 2014-05-20T15:31:49Z | |
dc.date.issued | 2009-04-01 | |
dc.description.abstract | "Isolation and evaluation of the biological activity related to the major alkaloids in Tabernaemontana angulata Mart. ex Mull Arg., Apocynaceae." Introducing-new chemotherapeutic agents is a, great demand. in the control of infections diseases.' Brazil is one of the richest countries in biodiversity and the Laboratorio de Extracao at UNIP has been collecting plants from. the Amazon and Atlantic Rain Forests with the aim of screening for new antibacterial and antitumor plant extracts. Previous studies demonstrated that the ethanol fraction obtained from the crude extract of Tabernaemontana angulata stems showed antibacterial activity against Staphylococcus aureus (ATCC 6538 in the microdilution broth assay. Two alkaloids were the major compounds in the active fraction, verified by thin layer chromatography analysis. In the present study, the total alkaloids were obtained from the crude extract and were fractionated by preparative thin layer chromatography for the isolation of the main components. The isolated. compounds were identified by GC/MS and (1)H-NMR as coronaridine,e and voacangine. The alkaloid fractions obtained from the isolation procedure were tested for antibacterial activity, but no activity was detected. | en |
dc.description.affiliation | Univ Estadual Paulista, Lab Extracao, BR-01310100 São Paulo, Brazil | |
dc.description.affiliation | Univ São Paulo, Inst Quim, BR-05513970 São Paulo, Brazil | |
dc.description.affiliation | Secretaria Meio Ambiente Estado São Paulo R Migue, Inst Bot, BR-04301902 São Paulo, Brazil | |
dc.description.affiliation | Univ Estadual Paulista, Programa Posgrad Engn Prod, Inst Ciencias Exatas & Tecnol, BR-04026002 São Paulo, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Lab Extracao, BR-01310100 São Paulo, Brazil | |
dc.description.affiliationUnesp | Univ Estadual Paulista, Programa Posgrad Engn Prod, Inst Ciencias Exatas & Tecnol, BR-04026002 São Paulo, Brazil | |
dc.format.extent | 626-631 | |
dc.identifier | http://dx.doi.org/10.1590/S0102-695X2009000400021 | |
dc.identifier.citation | Revista Brasileira de Farmacognosia-brazilian Journal of Pharmacognosy. Amsterdam: John Benjamins Publishing Company, v. 19, n. 2B, p. 626-631, 2009. | |
dc.identifier.file | S0102-695X2009000400021.pdf | |
dc.identifier.issn | 0102-695X | |
dc.identifier.scielo | S0102-695X2009000400021 | |
dc.identifier.uri | http://hdl.handle.net/11449/40855 | |
dc.identifier.wos | WOS:000271903600022 | |
dc.language.iso | por | |
dc.publisher | John Benjamins Publishing Company | |
dc.relation.ispartof | Revista Brasileira de Farmacognosia-brazilian Journal of Pharmacognosy | |
dc.relation.ispartofjcr | 1.596 | |
dc.rights.accessRights | Acesso aberto | |
dc.source | Web of Science | |
dc.subject | Tabernaemontana angulata | en |
dc.subject | Apocynaceae | en |
dc.subject | alkaloids | en |
dc.subject | antibacterial activity | en |
dc.subject | cytotoxicity | en |
dc.title | Isolamento e avaliação da atividade biológica dos alcalóides majoritários de Tabernaemontana angulata Mart. ex Müll. Arg., Apocynaceae | pt |
dc.title.alternative | Isolation and evaluation of the biological activity related to the major alkaloids in Tabernaemontana angulata Mart. ex Mull. Arg., Apocynaceae | en |
dc.type | Artigo | |
dcterms.rightsHolder | John Benjamins Publishing Company | |
dspace.entity.type | Publication | |
unesp.author.orcid | 0000-0001-5812-6667[2] | |
unesp.author.orcid | 0000-0002-2860-6659[3] | |
unesp.author.orcid | 0000-0002-5237-101X[5] |
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