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Engineering Microbial Living Therapeutics: The Synthetic Biology Toolbox

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dc.contributor.authorPedrolli, Danielle B. [UNESP]
dc.contributor.authorRibeiro, Nathan V. [UNESP]
dc.contributor.authorSquizato, Patrick N. [UNESP]
dc.contributor.authorde Jesus, Victor N. [UNESP]
dc.contributor.authorCozetto, Daniel A. [UNESP]
dc.contributor.authorTuma, Rafael B.
dc.contributor.authorGracindo, Amanda
dc.contributor.authorCesar, Mariana B.
dc.contributor.authorFreire, Paulo J.C.
dc.contributor.authorda Costa, Ana F.M.
dc.contributor.authorLins, Milca R.C.R.
dc.contributor.authorCorrea, Graciely G.
dc.contributor.authorCerri, Marcel O.
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2019-10-06T15:20:16Z
dc.date.available2019-10-06T15:20:16Z
dc.date.issued2019-01-01
dc.description.abstractMicrobes can be engineered to act like living therapeutics designed to perform specific actions in the human body. From fighting and preventing infections to eliminating tumors and treating metabolic disorders, engineered living systems are the next generation of therapeutics. In recent years, synthetic biologists have greatly expanded the genetic toolbox for microbial living therapeutics, adding sensors, regulators, memory circuits, delivery devices, and kill switches. These advances have paved the way for successful engineering of fully functional living therapeutics, with sensing, production, and biocontainment devices. However, some important tools are still missing from the box. In this review, we cover the most recent biological parts and approaches developed and describe the missing tools needed to build robust living therapeutics.en
dc.description.affiliationUniversidade Estadual Paulista (UNESP) School of Pharmaceutical Sciences Department of Bioprocess and Biotechnology Members of Team AQA Unesp at iGEM 2017
dc.description.affiliationUnespUniversidade Estadual Paulista (UNESP) School of Pharmaceutical Sciences Department of Bioprocess and Biotechnology Members of Team AQA Unesp at iGEM 2017
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipUniversidade Estadual Paulista
dc.description.sponsorshipIdFAPESP: #2014/17564-7
dc.format.extent100-115
dc.identifierhttp://dx.doi.org/10.1016/j.tibtech.2018.09.005
dc.identifier.citationTrends in Biotechnology, v. 37, n. 1, p. 100-115, 2019.
dc.identifier.doi10.1016/j.tibtech.2018.09.005
dc.identifier.issn1879-3096
dc.identifier.issn0167-7799
dc.identifier.scopus2-s2.0-85054569702
dc.identifier.urihttp://hdl.handle.net/11449/186933
dc.language.isoeng
dc.relation.ispartofTrends in Biotechnology
dc.rights.accessRightsAcesso restritopt
dc.sourceScopus
dc.subjectdesigner probiotics
dc.subjectdrug delivery
dc.subjectengineered microorganisms
dc.subjectliving therapeutics
dc.subjectsynthetic biology
dc.titleEngineering Microbial Living Therapeutics: The Synthetic Biology Toolboxen
dc.typeResenhapt
dspace.entity.typePublication
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.orcid0000-0002-3034-6497[1]
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt

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Araraquara - FCF - Faculdade de Ciências Farmacêuticas