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Hylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus ('spotted treefrog')

dc.contributor.authorCastro, Mariana S.
dc.contributor.authorFerreira, Tania Cristina G.
dc.contributor.authorCilli, Eduardo Maffud [UNESP]
dc.contributor.authorCrusca, Edson [UNESP]
dc.contributor.authorMendes Giannini, Maria José Soares [UNESP]
dc.contributor.authorSebben, Antonio
dc.contributor.authorRicart, Carlos Andre
dc.contributor.authorSousa, Marcelo V.
dc.contributor.authorFontes, Wagner
dc.contributor.institutionUniversidade de Brasília (UnB)
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.date.accessioned2014-05-20T14:17:42Z
dc.date.available2014-05-20T14:17:42Z
dc.date.issued2009-02-01
dc.description.abstractRP-HPLC fractionation of the electrically stimulated skin secretion of the arboreal South American frog Hypsiboas albopunctaturs (spotted treefrog) led to the isolation of a cytolytic C-terminally amidated peptide. This novel peptide, named hylin a1 (Hy-a1), consists of 18 amino acid residues (IFGAILPLALGALKNLIK-NH(2)). The alpha-helical structure of the synthetic hylin a1 peptide was confirmed by CID spectroscopy in the presence of 60% (v/v) TFE. The synthetic peptide displayed broad-spectrum antimicrobial activity against Gram-negative and Gram-positive bacteria including Escherichia coli, Staphylococcus aureus, Enterococcus faecalis, Bacillus subtilis and Pseudomonas aeruginosa and also against fungi (Candida albicans, C. krusei, C. parapsilosis and Cryptococcus neoformans). Hylin a1 was also able to disrupt human erytrocytes (HC(50) = 18 mu M). Similarity analysis using PSI-BLAST revealed 50-44% of identity to maximins Hv, H16, H15 and H10 from Bombina maxima and also to hylins b1 and b2 (Hy-b1 and Hy-b2) from Hypsiboas lundii (synonym: Hyla biobeba). (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade de Brasilia (UnB), Toxinol Lab, Dept Physiol Sci, BR-70910900 Brasilia, DF, Brazil
dc.description.affiliationUniversidade de Brasilia (UnB), Dept Cell Biol, Brazilian Ctr Prot Res, BR-70910900 Brasilia, DF, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Inst Chem, Dept Biochem & Chem Technol, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Inst Chem, Dept Biochem & Chem Technol, BR-14800900 Araraquara, SP, Brazil
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Pharmaceut Sci, Dept Clin Anal, BR-14800900 Araraquara, SP, Brazil
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFinanciadora de Estudos e Projetos (FINEP)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipFundação de Empreendimentos Científicos e Tecnológicos (FINATEC)
dc.description.sponsorshipFUB/UnB
dc.format.extent291-296
dc.identifierhttp://dx.doi.org/10.1016/j.peptides.2008.11.003
dc.identifier.citationPeptides. New York: Elsevier B.V., v. 30, n. 2, p. 291-296, 2009.
dc.identifier.doi10.1016/j.peptides.2008.11.003
dc.identifier.issn0196-9781
dc.identifier.lattes9424346762460416
dc.identifier.orcid0000-0002-8059-0826
dc.identifier.orcid0000-0002-4767-0904
dc.identifier.urihttp://hdl.handle.net/11449/25306
dc.identifier.wosWOS:000263447700014
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofPeptides
dc.relation.ispartofjcr2.851
dc.relation.ispartofsjr1,001
dc.rights.accessRightsAcesso restritopt
dc.sourceWeb of Science
dc.subjectAmphibianen
dc.subjectHypsiboasen
dc.subjectSkin secretionen
dc.subjectHemolysisen
dc.subjectAntimicrobial peptideen
dc.titleHylin a1, the first cytolytic peptide isolated from the arboreal South American frog Hypsiboas albopunctatus ('spotted treefrog')en
dc.typeArtigopt
dcterms.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dcterms.rightsHolderElsevier B.V.
dspace.entity.typePublication
relation.isDepartmentOfPublicationa83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isDepartmentOfPublication.latestForDiscoverya83d26d6-5383-42e4-bb3c-2678a6ddc144
relation.isOrgUnitOfPublication95697b0b-8977-4af6-88d5-c29c80b5ee92
relation.isOrgUnitOfPublicationbc74a1ce-4c4c-4dad-8378-83962d76c4fd
relation.isOrgUnitOfPublication.latestForDiscovery95697b0b-8977-4af6-88d5-c29c80b5ee92
unesp.author.lattes9424346762460416
unesp.author.orcid0000-0002-4767-0904[3]
unesp.author.orcid0000-0002-8059-0826[5]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Química, Araraquarapt
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Ciências Farmacêuticas, Araraquarapt
unesp.departmentAnálises Clínicas - FCFpt
unesp.departmentBioquímica e Tecnologia - IQpt

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