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Publicação:
The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats

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dc.contributor.authorAzevedo, Vera Lucia Fernandes de [UNESP]
dc.contributor.authorSantos, Paulo Sergio Santana [UNESP]
dc.contributor.authorOliveira Jr, Gildàsio Silveira de
dc.contributor.authorMódolo, Gabriel Pinheiro
dc.contributor.authorDomingues, Maria Aparecida Custódio [UNESP]
dc.contributor.authorCastiglia, Yara Marcondes Machado [UNESP]
dc.contributor.authorVianna, Pedro Thadeu Galvão [UNESP]
dc.contributor.authorVane, Luiz Antonio [UNESP]
dc.contributor.authorMódolo, Norma Sueli Pinheiro [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionNorthwestern University (NU)
dc.contributor.institutionSanta Casa Faculty of Medicine of São Paulo
dc.contributor.institutionFeinberg School of Medicine
dc.contributor.institutionSanta Casa Faculty of Medicine
dc.date.accessioned2014-05-20T13:37:10Z
dc.date.accessioned2022-04-29T06:48:19Z
dc.date.available2014-05-20T13:37:10Z
dc.date.available2022-04-29T06:48:19Z
dc.date.issued2013-01-01
dc.description.abstractPURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion.en
dc.description.affiliationSanta Casa Faculty of Medicine of São Paulo
dc.description.affiliationUNESP Botucatu Medical School Postgraduate Program in Anesthesiology
dc.description.affiliationNorthwestern University Feinberg School of Medicine Department of Anesthesiology
dc.description.affiliationUNESP Botucatu Medical School Department of Pathology
dc.description.affiliationPostgraduate Program in Anesthesiology Botucatu Medical School, UNESP, Sao Paulo
dc.description.affiliationDepartment of Anesthesiology Northwestern University Feinberg School of Medicine, Chicago, IL
dc.description.affiliationDepartment of Pathology Botucatu Medical School, UNESP, Sao Paulo
dc.description.affiliationDepartment of Anesthesiology Botucatu Medical School, UNESP, Sao Paulo
dc.description.affiliationUnespUNESP Botucatu Medical School Postgraduate Program in Anesthesiology
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Pathology
dc.description.affiliationUnespUNESP Botucatu Medical School Department of Anesthesiology
dc.description.affiliationUnespPostgraduate Program in Anesthesiology Botucatu Medical School, UNESP, Sao Paulo
dc.description.affiliationUnespDepartment of Pathology Botucatu Medical School, UNESP, Sao Paulo
dc.description.affiliationUnespDepartment of Anesthesiology Botucatu Medical School, UNESP, Sao Paulo
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIdFAPESP: 10/08562-0
dc.format.extent05-09
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502013000100002
dc.identifier.citationActa Cirúrgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 05-09, 2013.
dc.identifier.citationActa Cirurgica Brasileira, v. 28, n. 1, p. 5-9, 2013.
dc.identifier.doi10.1590/S0102-86502013000100002
dc.identifier.fileS0102-86502013000100002.pdf
dc.identifier.issn0102-8650
dc.identifier.issn1678-2674
dc.identifier.lattes8223546475724058
dc.identifier.lattes7802830125342070
dc.identifier.lattes0585723113037140
dc.identifier.scieloS0102-86502013000100002
dc.identifier.scopus2-s2.0-84872905611
dc.identifier.urihttp://hdl.handle.net/11449/250375
dc.identifier.wosWOS:000313866600001
dc.language.isoeng
dc.publisherSociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartofActa Cirúrgica Brasileira
dc.relation.ispartofsjr0,395
dc.rights.accessRightsAcesso aberto
dc.sourceSciELO
dc.sourceScopus
dc.subjectAcute kidney injury
dc.subjectColloids
dc.subjectFluid therapy
dc.subjectHetastarch
dc.subjectRats
dc.titleThe effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in ratsen
dc.typeArtigo
dspace.entity.typePublication
unesp.author.lattes8223546475724058
unesp.author.lattes7802830125342070
unesp.author.lattes0585723113037140
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt
unesp.departmentAnestesiologia - FMBpt
unesp.departmentPatologia - FMBpt

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Botucatu - FMB - Faculdade de Medicina