Fluoride and phosphate release from fluoride varnishes supplemented with nano-sized sodium trimetaphosphate
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Purpose: The addition of sodium trimetaphosphate (TMP) to fluoride (F) varnishes has been shown to be effective in controlling dental caries and erosive tooth wear. This study evaluated the amount of F and phosphate (P) released from fluoride varnishes containing micrometric or nano-sized sodium trimetaphosphate (TMPmicro or TMPnano, respectively). Methods: The experimental varnishes included a placebo formulation (no F or TMP), 2.5% NaF, 5% NaF, 5% NaF + 5% TMPmicro, 5% NaF + 5% TMPnano, 5%NaF + 2.5% TMPnano, and commercial varnish (Duraphat, 5% NaF). Varnishes were applied on polyester sheets (n=8/group) and alternately immersed in remineralizing or demineralizing solutions at 30, 60, 90, 120, 180, 240, 300, 360, 420, 540, 600, 720, 780, 960, 1200 and 1440 min after first immersion. F and P release were analyzed with an ion-selective electrode and colorimetrically, respectively. Data were analyzed by 2-way, repeated measures ANOVA and Stu-dent-Newman-Keuls’ test (p<0.05). Results: Overall, varnishes containing TMPnano released significantly higher amounts of F in comparison with TMPmicro. Regarding the cumulative release of P, the varnishes containing TMP showed a constant increase up to 12 h. Conclusions: It was concluded that F release was significantly increased in TMP-containing formulations, and that the nanosized TMP further enhanced such effects, without affecting phosphate release.
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Fluorine, Nanoparticles, Polyphosphates, Sodium Fluoride
Language
English
Citation
Fluoride, v. 57, n. 1, 2024.
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