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Antimicrobial and Antibiofilm Effect of Brazilian Green Propolis Aqueous Extract against Dental Anaerobic Bacteria

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dc.contributor.authorde Sá Assis, Maria Angélica [UNESP]
dc.contributor.authorde Paula Ramos, Lucas [UNESP]
dc.contributor.authorAbu Hasna, Amjad [UNESP]
dc.contributor.authorde Queiroz, Talita Suelen [UNESP]
dc.contributor.authorPereira, Thaís Cristine [UNESP]
dc.contributor.authorNagai de Lima, Patrícia Michelle [UNESP]
dc.contributor.authorBerretta, Andresa Aparecida
dc.contributor.authorMarcucci, Maria Cristina [UNESP]
dc.contributor.authorTalge Carvalho, Cláudio Antonio [UNESP]
dc.contributor.authorde Oliveira, Luciane Dias [UNESP]
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)
dc.contributor.institutionApis Flora Industrial e Comercial Ltda.
dc.date.accessioned2023-07-29T12:41:16Z
dc.date.available2023-07-29T12:41:16Z
dc.date.issued2022-12-01
dc.description.abstractGreen propolis may represent a promising therapeutic alternative against dental anaerobic pathogens because of its antimicrobial action. This study aimed to evaluate the antimicrobial and antibiofilm actions of Brazilian green propolis aqueous extract (BGP-AqExt) against dental anaerobic bacteria. The minimum inhibitory concentration (MIC) and minimum microbicide concentration (MMC) of the extract were determined against the standard strains (ATCC) of Fusobacterium nucleatum, Parvimonas micra, Prevotella intermedia, Porphyromonas gingivalis and Porphyromonas endodontalis. BGP-AqExt was chemically characterized by high-performance liquid chromatography with diode-array detection (HPLC-DAD) analysis. Antibiofilm action was measured by MTT and crystal violet tests. The data were statistically analyzed by ANOVA and Tukey (5%) tests. The extract had antimicrobial action against all tested anaerobic bacteria, with an MIC value of 55 mg/mL for all bacteria, an MMC of 27.5 mg/mL for F. nucleatum and P. micra and 55 mg/mL for P. intermedia. Chemically, BGP-AqExt is composed of quercetin, gallic acid, caffeic and p-coumaric acid, drupani, kaempferol and Artepillin C. Significant reductions in biomass and metabolic action of biofilms were found after BGP-AqExt application. Therefore, BGP-AqExt has an antimicrobial and antibiofilm effect against dental anaerobic bacteria.en
dc.description.affiliationDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (ICT-UNESP)
dc.description.affiliationDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP)
dc.description.affiliationResearch and Development Laboratory Apis Flora Industrial e Comercial Ltda., Rua Triunfo, 945
dc.description.affiliationUnespDepartment of Biosciences and Oral Diagnosis Institute of Science and Technology São Paulo State University (ICT-UNESP)
dc.description.affiliationUnespDepartment of Restorative Dentistry Endodontics Division Institute of Science and Technology São Paulo State University (ICT-UNESP)
dc.identifierhttp://dx.doi.org/10.3390/molecules27238128
dc.identifier.citationMolecules, v. 27, n. 23, 2022.
dc.identifier.doi10.3390/molecules27238128
dc.identifier.issn1420-3049
dc.identifier.scopus2-s2.0-85143739387
dc.identifier.urihttp://hdl.handle.net/11449/246451
dc.language.isoeng
dc.relation.ispartofMolecules
dc.sourceScopus
dc.subjectanaerobic bacteria
dc.subjectantimicrobial action
dc.subjectgreen propolis
dc.titleAntimicrobial and Antibiofilm Effect of Brazilian Green Propolis Aqueous Extract against Dental Anaerobic Bacteriaen
dc.typeArtigopt
dspace.entity.typePublication
unesp.author.orcid0000-0002-1112-985X[3]
unesp.author.orcid0000-0001-5719-1301[7]
unesp.author.orcid0000-0002-8065-5618[8]
unesp.campusUniversidade Estadual Paulista (UNESP), Instituto de Ciência e Tecnologia, São José dos Campospt

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São José dos Campos - ICT - Instituto de Ciência e Tecnologia