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Labeling index in pituitary adenomas evaluated by means of MIB-1: is there a prognostic role? A critical review

dc.contributor.authorPires de Aguiar, Paulo Henrique [UNESP]
dc.contributor.authorAires, Rogerio
dc.contributor.authorLaws, Edward R.
dc.contributor.authorIsolan, Gustavo Rassier
dc.contributor.authorLogullo, Angela
dc.contributor.authorPatil, Chirag
dc.contributor.authorKatznelson, Laurence
dc.contributor.institutionUniversidade Estadual Paulista (Unesp)
dc.contributor.institutionSanta Casa de Londrina Hosp
dc.contributor.institutionBrigham & Womens Hosp
dc.contributor.institutionUniversidade Federal do Rio Grande do Sul (UFRGS)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionStanford Univ
dc.date.accessioned2014-05-20T15:33:33Z
dc.date.available2014-05-20T15:33:33Z
dc.date.issued2010-12-01
dc.description.abstractObjective: The present article presents an overview of the literature, and analyses the methods and the primary questions related to assessment of proliferation index using the Ki-67/MIB-1 labeling index in pituitary adenomas. Although atypical adenomas are characterized by their atypical morphological features by an elevated mitotic index, a Ki-67 (MIB-1) labeling index greater than 3% and extensive nuclear staining for p53, use of the proliferation index (LI) of pituitary adenomas in assessing the degree of tumor aggressiveness is a controversial topic in the literature, and there are disparate results involving many studies.Methods: A review of literature was carried out to correlate the role of Ki-67 LI and its correlation with clinical findings, tumor size, invasiveness, recurrence, adenoma subtype, adenoma doubling time, and pituitary carcinomas is addressed. Results: The prognosis cannot be predicted on the basis of the Ki-67 LI alone. Although there is no direct relation between Ki-67 LI and some of these variables and controversial data were found regarding some topics, our review justify the use of Ki-67 in the analysis of pituitary adenomas as an additional information for clinical decision.Conclusion: Although assessment of proliferative may be helpful in predicting subsequent tumor recurrence or invasiveness, there are many other important and as yet unidentified factors pituitary tumors. It is clear that further research is needed to clarify these molecular mechanisms to predict those with a potentially poor clinical outcome.en
dc.description.affiliationState Univ São Paulo, São Paulo Med Sch, Dept Neurol, São Paulo, Brazil
dc.description.affiliationSanta Casa de Londrina Hosp, Div Neurosurg, Londrina, Brazil
dc.description.affiliationBrigham & Womens Hosp, Dept Neurosurg, Boston, MA 02115 USA
dc.description.affiliationUniversidade Federal do Rio Grande do Sul (UFRGS), Dept Neurosurg & Postgrad Surg, Porto Alegre, RS, Brazil
dc.description.affiliationUniv Fed São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationStanford Univ, Dept Neurosurg, Stanford Pituitary Ctr, Stanford, CA 94305 USA
dc.description.affiliationUnespState Univ São Paulo, São Paulo Med Sch, Dept Neurol, São Paulo, Brazil
dc.format.extent1060-1071
dc.identifierhttp://dx.doi.org/10.1179/016164110X12670144737855
dc.identifier.citationNeurological Research. Leeds: Maney Publishing, v. 32, n. 10, p. 1060-1071, 2010.
dc.identifier.doi10.1179/016164110X12670144737855
dc.identifier.issn0161-6412
dc.identifier.urihttp://hdl.handle.net/11449/42138
dc.identifier.wosWOS:000283422300008
dc.language.isoeng
dc.publisherManey Publishing
dc.relation.ispartofNeurological Research
dc.relation.ispartofjcr1.449
dc.relation.ispartofsjr0,592
dc.rights.accessRightsAcesso abertopt
dc.sourceWeb of Science
dc.subjectPituitary adenomasen
dc.subjectLabeling indexen
dc.subjectCell growthen
dc.subjectInvasionen
dc.subjectMIB-1en
dc.subjectKi-67en
dc.titleLabeling index in pituitary adenomas evaluated by means of MIB-1: is there a prognostic role? A critical reviewen
dc.typeArtigopt
dcterms.licensehttp://maneypublishing.com/index.php/resources/authors/copyright_and_permissions_information_for_authors/
dcterms.rightsHolderManey Publishing
dspace.entity.typePublication
unesp.campusUniversidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatupt

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