Publicação: Labeling index in pituitary adenomas evaluated by means of MIB-1: is there a prognostic role? A critical review
dc.contributor.author | Pires de Aguiar, Paulo Henrique [UNESP] | |
dc.contributor.author | Aires, Rogerio | |
dc.contributor.author | Laws, Edward R. | |
dc.contributor.author | Isolan, Gustavo Rassier | |
dc.contributor.author | Logullo, Angela | |
dc.contributor.author | Patil, Chirag | |
dc.contributor.author | Katznelson, Laurence | |
dc.contributor.institution | Universidade Estadual Paulista (Unesp) | |
dc.contributor.institution | Santa Casa de Londrina Hosp | |
dc.contributor.institution | Brigham & Womens Hosp | |
dc.contributor.institution | Universidade Federal do Rio Grande do Sul (UFRGS) | |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | |
dc.contributor.institution | Stanford Univ | |
dc.date.accessioned | 2014-05-20T15:33:33Z | |
dc.date.available | 2014-05-20T15:33:33Z | |
dc.date.issued | 2010-12-01 | |
dc.description.abstract | Objective: The present article presents an overview of the literature, and analyses the methods and the primary questions related to assessment of proliferation index using the Ki-67/MIB-1 labeling index in pituitary adenomas. Although atypical adenomas are characterized by their atypical morphological features by an elevated mitotic index, a Ki-67 (MIB-1) labeling index greater than 3% and extensive nuclear staining for p53, use of the proliferation index (LI) of pituitary adenomas in assessing the degree of tumor aggressiveness is a controversial topic in the literature, and there are disparate results involving many studies.Methods: A review of literature was carried out to correlate the role of Ki-67 LI and its correlation with clinical findings, tumor size, invasiveness, recurrence, adenoma subtype, adenoma doubling time, and pituitary carcinomas is addressed. Results: The prognosis cannot be predicted on the basis of the Ki-67 LI alone. Although there is no direct relation between Ki-67 LI and some of these variables and controversial data were found regarding some topics, our review justify the use of Ki-67 in the analysis of pituitary adenomas as an additional information for clinical decision.Conclusion: Although assessment of proliferative may be helpful in predicting subsequent tumor recurrence or invasiveness, there are many other important and as yet unidentified factors pituitary tumors. It is clear that further research is needed to clarify these molecular mechanisms to predict those with a potentially poor clinical outcome. | en |
dc.description.affiliation | State Univ São Paulo, São Paulo Med Sch, Dept Neurol, São Paulo, Brazil | |
dc.description.affiliation | Santa Casa de Londrina Hosp, Div Neurosurg, Londrina, Brazil | |
dc.description.affiliation | Brigham & Womens Hosp, Dept Neurosurg, Boston, MA 02115 USA | |
dc.description.affiliation | Universidade Federal do Rio Grande do Sul (UFRGS), Dept Neurosurg & Postgrad Surg, Porto Alegre, RS, Brazil | |
dc.description.affiliation | Univ Fed São Paulo, Dept Pathol, São Paulo, Brazil | |
dc.description.affiliation | Stanford Univ, Dept Neurosurg, Stanford Pituitary Ctr, Stanford, CA 94305 USA | |
dc.description.affiliationUnesp | State Univ São Paulo, São Paulo Med Sch, Dept Neurol, São Paulo, Brazil | |
dc.format.extent | 1060-1071 | |
dc.identifier | http://dx.doi.org/10.1179/016164110X12670144737855 | |
dc.identifier.citation | Neurological Research. Leeds: Maney Publishing, v. 32, n. 10, p. 1060-1071, 2010. | |
dc.identifier.doi | 10.1179/016164110X12670144737855 | |
dc.identifier.issn | 0161-6412 | |
dc.identifier.uri | http://hdl.handle.net/11449/42138 | |
dc.identifier.wos | WOS:000283422300008 | |
dc.language.iso | eng | |
dc.publisher | Maney Publishing | |
dc.relation.ispartof | Neurological Research | |
dc.relation.ispartofjcr | 1.449 | |
dc.relation.ispartofsjr | 0,592 | |
dc.rights.accessRights | Acesso aberto | pt |
dc.source | Web of Science | |
dc.subject | Pituitary adenomas | en |
dc.subject | Labeling index | en |
dc.subject | Cell growth | en |
dc.subject | Invasion | en |
dc.subject | MIB-1 | en |
dc.subject | Ki-67 | en |
dc.title | Labeling index in pituitary adenomas evaluated by means of MIB-1: is there a prognostic role? A critical review | en |
dc.type | Artigo | pt |
dcterms.license | http://maneypublishing.com/index.php/resources/authors/copyright_and_permissions_information_for_authors/ | |
dcterms.rightsHolder | Maney Publishing | |
dspace.entity.type | Publication | |
unesp.campus | Universidade Estadual Paulista (UNESP), Faculdade de Medicina, Botucatu | pt |
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